基于文献计量学分析代谢组学在中医证型研究领域的应用  

Metabolomics applied in Chinese medicine syndromes: a bibliometric analysis

作　　者：何静[1] 孙志岭[1] 谢彤[2] 焦文娟 张永怡[1] He Jing1, Sun Zhi-ling1, Xie Tong2, Jiao Wen-juan1, Zhang Yong-yi1(1.College of Nursing, 2.Institute of Chinese Medicine for Pediatrics, Nanjing University of Chinese Medicine, Nanjing 210023, Jiangsu Province, Chin)

机构地区：[1]南京中医药大学护理学院,江苏省南京市210000 [2]南京中医药大学中医儿科学研究所,江苏省南京市210000

出　　处：《中国组织工程研究》2018年第16期2613-2618,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金面上项目(81774383);江苏省普通高校学术学位研究生科研创新计划项目(KYLX16-1164)~~

摘　　要：背景:代谢组学是以组群指标分析为基础,以高通量检测和数据处理为手段,以信息建模和系统整合为目标的系统生物学分支,其方法适用于识别代谢指标,可以为个体化诊疗、诊断提供依据,更好指导临床辨证论治。目的:分析建库至今以来代谢组学在中医证型研究领域应用的文献特征和研究现状,为该组学技术在中医证型研究领域的应用提供借鉴。方法:以中国知网、万方数据库、中国生物医学文献数据库、Pub Med、Web of science、Medline数据库为资料来源,检索建库至2017年6月收录的中医证型研究领域应用代谢组学的文献,建立文献数据库,采用文献计量学及数据挖掘的方法,对其文献特征及研究特征进行统计分析。结果与结论:(1)纳入499篇,期刊文献371篇(74.35%),会议论文30篇(6.01%),学位论文98篇(19.64%)。371篇关于代谢组学在中医证型研究领域应用的期刊文献共分布在124种期刊上,其中中文核心期刊32种,占总文献量的45.28%;SCI收录期刊10种,占总文献量的3.77%;(2)根据文献内容统计分类得到7类病症系统(以消化系统和循环系统为主),涉及23种疾病,39种干预措施;(3)中医证型研究领域应用代谢组学技术辨证分型的统一化、标准化仍有待提高,同时文献的质量也相对欠缺。应加强提高动物实验类研究的质量,探讨疾病证型本质及干预措施机制,以期控制疾病的发生发展。BACKGROUND： Metabolomics is a branch of systems biology taking systematic study, high-throughput detection and data processing as means, information modeling and systematic integration as targets, which canbe used for recognizing metabolic indexes, provide evidence for individualized diagnosis and treatment and guide syndrome differentiation in the clinic. OBJECTIVE： To analyze the literature features and research status of metabolomics applied in the field of Chinese medicine syndromes so as to provide reference for its application in Chinese medicine syndromes. METHODS： Databases of CNKI, Wan Fang, CBM, Pub Med, Web of Science and Medline were retrieved for the articles addressing metabolomics applied in Chinese medicine syndromes published before June 2017. The literature database was established, and then the literature and research features were analyzed using bibliometrics and data mining. RESULTS AND CONCLUSION： Totally 499 articles were enrolled, including 371 journal articles from journals（74.35%）, 30 conference papers（6.01）, 98 dissertations（19.64）, and the 371 journal papers were published in 124 journals（32 of Chinese core journals（45.28%）, and 10 SCI cited journals（3.77%））. In the articles, 7 types of disease systems（mainly in digestive system and circulatory system） were classified according to the statistics, involving 23 diseases and 39 interventions. In summary, there is still a lack of standardized classification for metabolomics applied in Chinese medicine syndromes and the quality of literature is poor. We should conduct more animal experiments and explore the essence and intervention measurements of syndromes, thereby controlling the disease occurrence and development.

关 键 词：代谢 蛋白质组学 医学 中国传统 文献计量学 组织工程 代谢组学 中医证型 组织构建 

分 类 号：R318[医药卫生—生物医学工程]