冠状动脉粥样硬化患者血脂及修饰化脂蛋白水平研究  

Study on the blood lipid and the modified lipoprotein level in patients with coronary atherosclerosis

作　　者：罗薇 郭英[1] 都向阳[1] 丁霏 李小玲[1] 贺勇[1] 聂鑫[1] 宋昊岚[1] 李贵星[1] LUO Wei;GUO Ying;DU Xiangyang;DING Fei;LI Xiaoling;HE Yong;NIE Xin;SONG Haolan;LI Guixing(Department of Laboratory Medicine,West China Hospital of Sickuan University,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西医院实验医学科,成都610041

出　　处：《检验医学与临床》2018年第12期1749-1752,共4页Laboratory Medicine and Clinic

基　　金：四川省科技支撑项目(2016SC0044)

摘　　要：目的分析冠状动脉粥样硬化患者血脂、修饰化脂蛋白及脂蛋白相关磷脂酶A2水平,探究修饰化脂蛋白及脂蛋白相关磷脂酶A2与冠状动脉粥样硬化发生的关系。方法选取2016年9-12月因急性心肌梗死就诊于华西医院急诊科、最终诊断为冠状动脉粥样硬化性心脏病患者220例作为病例组,以同期在该院体检中心健康体检者200例作为对照组,比较病例组和对照组血脂及修饰化脂蛋白水平的差异。结果病例组空腹血糖、糖化血红蛋白高于对照组,胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇水平低于对照组,差异均有统计学意义(P<0.05),三酰甘油水平两组差异无统计学意义(P>0.05)。病例组氧化低密度脂蛋白、氧化高密度脂蛋白、糖化低密度脂蛋白、糖化高密度脂蛋白、脂蛋白相关磷脂酶A2水平均高于对照组,差异均有统计学意义(P<0.05)。结论血脂不是冠状动脉粥样硬化发生和发展的主要因素,高血糖和高水平修饰化脂蛋白及脂蛋白相关磷脂酶A2与冠状动脉粥样硬化的形成关系密切。Objective To analyze the levels of serum lipid,modified lipoprotein and lipoprotein related phospholipase A2 in patients with coronary atherosclerosis,and to explore the relationship between modified lipoprotein and lipoprotein related phospholipase A2 and the occurrence of coronary atherosclerosis.MethodsA total of 220 cases who came to Emergency Department of West China Hospital from September 2016 to December 2016 due to acute myocardial infarction and were diagnosed as coronary atherosclerotic were taken as a case group,200 healthy individual were taken as a control group.The differences of serum lipids and modified lipoprotein levels between case group and control group were compared.Results The fasting blood glucose and glycated hemoglobin in the case group were higher than those of the control group（P〈0.05）.There was no significant difference on the level of triacylglycerol（P〈0.05）.The levels of cholesterol,high density lipoprotein cholesterol and low density lipoprotein cholesterol in the case group were lower than those in the control group,and the differences were statistically significant（P〈0.05）.The levels of oxidized low density lipoprotein,oxidized high density lipoprotein,glycosylatedlow density lipoprotein,glycosylated high density lipoprotein and lipoprotein related phospholipase A2 in the case group were all higher than those in the control group,and the differences were statistically significant（P〈0.05）.Conclusion Blood lipid is not a major factor in the occurrence and development of coronary atherosclerosis.Hyperglycemia,high level of modified lipoprotein and lipoprotein related phospholipase A2 are closely related to the formation of coronary atherosclerosis.

关 键 词：心肌梗死 冠状动脉粥样硬化 修饰化脂蛋白 脂蛋白相关磷脂酶A2 

分 类 号：R543.3[医药卫生—心血管疾病]