龙眼肉乙醇提取物对雌性大鼠垂体-性腺轴的作用  

The effect of ethanol extract pseudo-seed coat of Euphoria longan steud on pituitary-gonad axis in female rats

作　　者：许兰芝[1] 王洪岗[1] 耿秀芳[2] 冷萍[2] 

机构地区：[1]潍坊医学院,山东潍坊261042 [2]潍坊市人民医院,山东潍坊261042

出　　处：《中医药信息》2002年第5期57-58,共2页Information on Traditional Chinese Medicine

摘　　要：目的 :观察龙眼肉乙醇提取物对大鼠垂体 -性腺轴的作用。方法 :龙眼肉乙醇提取物给大鼠ip。 2 5g·kg- 1 ·d- 1 、5g·kg- 1 ·d- 1 ,共 1 0天 ,颈总动脉取血 ,用放射免疫法测定大鼠血浆中FSH、E2 、P、LH、T、PRL的含量。结果 :龙眼肉乙醇提取物明显降低雌性大鼠血浆中PRL、E2 、T的含量 (P <0 0 1 ) ,增加其FSH、P的含量 (P <0 0 1 )。但是对LH的含量无影响。结论 :龙眼肉乙醇提取物明显影响大鼠垂体 -性腺轴的内分泌机能。Objective:To explore the effect of ethanol extract of pseudo seed coat of Euphoria longan steud(EELS) on endocrine function of pituitary gonad axis in female rats. Methods:PRL、E 2、P、T、FSH、LH in rats blood serum were measured by radiodmmunoassay method(RIA). Result:EELS(crude drug2 5g·kg -1 、5 0g·kg -1 )could significantly decreased content of PRL、E 2 and T( P <0 01) and markedly enhance content of FSH and P( P< 0 01),but could not alter content of LH ( P >0 05).Conclustion:EELS inhibit the secretion of prolactim but promote secretion of estradiol and follicle stimulating hormone.

关 键 词：龙眼肉乙醇提取物 垂体-性腺轴 内分泌机能 龙眼 药理学 

分 类 号：R285[医药卫生—中药学]