透明质酸-胶原-生物玻璃支架材料的制备及矿化性能研究  

Preparation and mineralization evaluation of hyaluronic acid-collagen-bioglass scaffolds

作　　者：杨春蓉 YANG Chunrong(School of Materials Science and Engineering,Fujian University of Technology,Fuzhou 350118,China)

机构地区：[1]福建工程学院材料科学与工程学院,福建福州350118

出　　处：《福建工程学院学报》2018年第3期215-218,共4页Journal of Fujian University of Technology

基　　金：国家自然科学基金项目(51702052);福建工程学院科研发展基金项目(GY-Z15093);福建工程学院科研启动基金项目(GY-Z0854)

摘　　要：以透明质酸、胶原和生物玻璃为原料制备复合支架材料,并对其矿化性能进行研究。实验将透明质酸、胶原和生物玻璃按比例混合,再进行交联处理,冷冻干燥得到支架材料,最后将其浸入模拟体液进行矿化,分析生物分子在矿化过程中的作用机制。研究发现,该复合支架材料具有三维多孔的微观结构;在模拟体液中的矿化产物为羟基磷灰石。胶原蛋白和透明质酸对溶液中钙、磷离子的亲和力构成了矿化机制的基础。且两种生物分子可相互键合,促进钙化。该支架具有良好的矿化性能,可用于骨缺损的修复。Composite scaffolds were prepared using hyaluronic acid,collagen and bioglass and the mineralization characteristics were evaluated. Hyaluronic acid,collagen and bioactive glass were mixed in proportion,and then cross-linked and freeze dried. The obtained scaffolds were immersed in the simulated body fluid for mineralization,and the mechanism of biomolecules in the mineralization process was analyzed. It is found that the composite scaffold material has a three-dimensional porous microstructure. The mineralized product in the simulated body fluid is hydroxyapatite. The affinity of collagen and hyaluronic acid to calcium and phosphorus ions in the solution constitutes the basis of the mineralization mechanism. The two biological molecules can bond with each other to promote calcification. The scaffolds have good mineralization properties and can be used to repair bone defects.

关 键 词：支架 复合 矿化 

分 类 号：TB34[一般工业技术—材料科学与工程]