新诊断T2DM患者血清A-FABP及YKL-40水平与胰岛素抵抗的相关性研究  

Study on the Correlation Between Serum A-FABP And YKL-40 Levels and Insulin Resistance in Newly Diagnosed T2DM Patients

作　　者：于叶叶 石鑫 潘佳秋[1] 史为伍[2] 谭丽艳[1] 于学静[1] Yu Yeye;Shi Xin;Pan Jiaqiu;Shi Weiwu;Tan Liyan;Yu Xuejing(Department of Endocrinology;Department of Nephrology,the First Affiliated Hospital of Jiamusi University,Jiamusi 154003 China)

机构地区：[1]佳木斯大学附属第一医院内分泌科 [2]佳木斯大学附属第一医院肾内科,黑龙江佳木斯154003

出　　处：《锦州医科大学学报》2018年第3期17-21,共5页Journal of Jinzhou Medical University

基　　金：黑龙江省教育厅基本科研业务费基础研究项目;项目编号:2016-KYYWF-0587

摘　　要：目的探讨新诊断2型糖尿病患者血清A-FABP与YKL-40水平的变化及其与胰岛素抵抗的关系及二者之间的相关性。方法选取佳木斯大学附属第一医院内分泌科就诊的新诊断2型糖尿病患者60例(T2DM组),另选体检健康者60名作为健康对照组(NC组)。采用ELISA检测血清A-FABP和YKL-40水平。结果 T2DM组血清A-FABP和YKL-40水平均高于NC组,差异均有统计学意义(P<0.01);A-FABP与体重、BMI、腰围、臀围、WHR、FPG、Hb A1c、FIns、TG、HOMA-IR呈正相关,与QUICKI、HDL呈负相关(均P<0.05);YKL-40与FPG、Hb A1c、FIns、HOMA-IR呈正相关,与QUICKI、HDL呈负相关(均P<0.05);A-FABP与YKL-40呈正相关(P<0.05);多元逐步回归分析结果显示,HOMA-IR和BMI是血清A-FABP水平的独立影响因素,HOMA-IR和FPG是血清YKL-40水平的独立相关因素。结论 A-FABP可能参与调节YKL-40的生成,二者在胰岛素抵抗的发生发展中可能拥有共同的相关信号通路。Objective To investigate the relationship and correlation between serum A-FABP and YKL-40 levels and insulin resistance in newly diagnosed type 2 diabetic patients. Methods 60 newly diagnosed patients with type 2 diabetes mellitus treated in our hospital were selected as the experiment group（T2DM group） and 60 healthy subjects were chosen as the control group（NC group）.Serum A-FABP and YKL-40 levels were detected by ELISA. Results The levels of serum A-FABP and YKL-40 in T2DM group were higher than those in NC group,and the difference was statistically significant（P〈0. 01）. A-FABP was positively correlated with body weight,BMI,waist circumference,hip circumference,WHR,FPG,Hb A1 c,FIns,TG,HOMA-IR and negatively correlated with QUICKI and HDL（both P〈0. 05）. YKL-40 was positively correlated with FPG,Hb A1 c,FIns and HOMA-IR,and negatively correlated with QUICKI and HDL（both P〈0. 05）. A-FABP was positively correlated with YKL-40（P〈0. 05）. Multiple linear stepwise regression analysis showed that HOMA-IR and BMI were independent influencing factors on serum A-FABP levels,and HOMA-IR and FPG independently affect serum YKL-40 levels. Conclusion A-FABP may be involved in regulating the formation of ykl-40,and they may have a common signaling pathway in the occurrence and development of insulin resistance.

关 键 词：2型糖尿病 胰岛素抵抗 A-FABP YKL-40 

分 类 号：R587.1[医药卫生—内分泌]