1992-2016年我国乙型肝炎病毒携带率变化特点的Meta分析  

Changing characteristic of hepatitis B virus carrying rate in China form 1992 to 2016: a Meta-analysis

作　　者：段瑞波 刘立新[1,2] Duan Ruibo;Liu Lixin(Current Master Student,Department of Gastroenterology,First Hospital of Shanxi Medical University,Taiyuan 030001,China;Department of Gastroenterology,3 Experimental Center of Science and Research,First Hospital of Shanxi Medical University,Taiyuan 030001,China)

机构地区：[1]山西医科大学第一医院消化科 [2]山西医科大学第一医院科研实验中心,太原030001

出　　处：《中华消化病与影像杂志（电子版）》2018年第3期116-126,共11页Chinese Journal of Digestion and Medical Imageology(Electronic Edition)

摘　　要：目的评价我国近25年乙型肝炎病毒携带率的变化特点,明确乙型肝炎疫苗接种的意义,为临床防治提供依据。方法在Pubmed、Ovid、EMBASE、万方、维普和中国知网等中英文期刊全文数据库通过计算机检索、文献追溯、人工检索等途径收集1992-2016年已发表的乙型肝炎病毒携带率的研究报道,通过Meta分析方法对入选的50篇相关文献进行汇总和分析,得出乙型肝炎疫苗在我国接种以来乙型肝炎病毒携带率的变化特点。结果近25年我国乙型肝炎病毒携带率呈下降趋势,1992-2004年乙型肝炎病毒携带率为8%,2005-2016年为6%,2个时间段乙型肝炎携带率比较,差异具有统计学意义(P<0.05);2005-2016年我国不同地区乙型肝炎病毒携带率为东北4%、华北3%、华东7%、华中7%、西北5%、西南5%、华南8%。结论我国使用乙型肝炎疫苗25年来,乙型肝炎病毒携带率呈下降趋势,乙型肝炎病毒感染得到了有效控制;我国七个地区的携带率进行比较,华南地区携带率最高,华北和东北乙型肝炎携带率最低。Objective To evaluate the changing characteristics of hepatitis B virus（ HBV） carrying rate in recent 25 years in our country,clarify the significance of hepatitis B vaccination and provide the basis for clinical prevention and treatment. Methods Research reports on the published HBV carrying rates during 1992-2016 were collected by computerized searches,literature review,and manual searches through Pubmed,Ovid,EMBase,Wanfang,VIP and CNKI. The Meta-analysis method was used to summarize and analyze the selected 50 related articles,and conclude the changing characteristic of HBV carrying rate in China. Results The carrying rate of HBV in China was declining in the past 25 years. The difference in the carrying rate of HBV between 1992-2004 and 2005-2016 was statistically significant（ 8% vs. 6%,P〈 0. 05）.During 2005 to 2016,the HBV carrying rate of Northeast was 4%,North China 3%,East China 7%,Central China 7%,Northwest 5%,Southwest 5%,South China 8%. Conclusion In the past 25 years since China used hepatitis B vaccine,HBV carrying rate has showed a downward trend,and HBV infection has been effectively controlled. Carrying rates in seven regions of China are compared,with the highest HBV carrying rate in Southern China,the lowest carrying rate in North China and Northeast China.

关 键 词：乙型肝炎 乙型肝炎疫苗 HBSAG携带率 META分析 

分 类 号：R512.62[医药卫生—内科学]