高通量血液透析治疗尿毒症患者的效果观察  

The effect of high-flux hemodialysis on patients with uremia

作　　者：刘维佳[1] LiuWeijia(Department of Nephrology,First people＇s hospital of Xiantao city,Xiantao,Hubei,433000,China)

机构地区：[1]仙桃市第一人民医院肾病内科,湖北仙桃433000

出　　处：《当代医学》2018年第18期48-50,共3页Contemporary Medicine

摘　　要：目的分析高通量血液透析治疗尿毒症患者的临床疗效。方法选择2015年3月~2016年9月于本院进行血液透析的尿毒症患者92例为研究对象,使用随机数表法分为两组,各46例。给予对照组低通量血液透析,给予观察组高通量血液透析,对比两组患者透析1疗程后肾功能相关毒素水平,统计两组透析期间不良反应发生情况。结果经为期3个月的5次透析治疗后,两组血肌酐(Scr)、血素氮(BUN)水平对比,差异无统计学意义;观察组血清甲状旁腺激素(IPTH)、β2微球蛋白(β2-MG)水平明显低于对照组,差异具有统计学意义(P<0.05);两组透析期间低血压、感染不良反应发生率对比,差异无统计学意义。结论高通量血液透析可显著优化大分子毒素滤过率,对患者预后有积极影响。Objective To analyze the clinical efficacy of high-throughput hemodialysis for uremia patients. Methods 92 cases of uremia patients with hemodialysis in our hospital from March 2015 to September 2016 were selected as the study subjects, and the random number table method was divided into two groups, 46 cases in each group. To control low flux hemodialysis, giving observation group of high flux hemodialysis, compared two groups of patients after 1 course of kidney dialysis related toxin levels, statistics of two groups of adverse reaction happening during dialysis. Results Two groups of blood creatinine（Scr） and blood nitrogen（BUN） were compared between the two groups after 5 dialysis treatment for 3 months, and the difference was not statistically significant. The levels of serum parathyroid hormone（IPTH） and beta 2 microglobulin（β2-MG） in the observation group were significantly lower than those in the control group, and the difference was statistically significant（P〈0.05）. There was no significant difference in the incidence of hypotension and infection during dialysis. Conclusion High-throughput hemodialysis can significantly optimize the filtration rate of macromolecular toxin and have a positive effect on the prognosis of patients.

关 键 词：尿毒症 高通量 血液透析 临床疗效 

分 类 号：R692.5[医药卫生—泌尿科学]