长坤冲剂对顺铂致实验性急性肾功能衰竭大鼠的防治作用  

Preventing and Treating Effects of "Changkun Granules" on Experimental Acute Renal Failure Induced by Cisplatin in Rats

作　　者：邱玉文[1] 叶丽明[1] 冯伟成[1] 郭彤[1] 梁金强[1] 吴淑仪[1] 王雪英[1] 

机构地区：[1]广州市医药工业研究所,510240

出　　处：《中药材》2002年第8期571-573,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:观察长坤冲剂对顺铂致实验性急性肾功能衰竭(ARF)大鼠的防治作用。方法:用长坤冲剂给ARF大鼠灌胃,检测大鼠血清尿素氮(BUN)和血肌苷(SCr),并取肾脏作病理组织学检查。结果:长坤冲剂能明显降低由顺铂引起的大鼠的BUN升高,同时可见肾脏组织学损害明显减轻。结论:提示长坤冲剂对实验性ARF大鼠有一定的防治作用。Objective: To study the preventing and treating effects of 'Changkun Granules' in experimental acute renal failure(ARF) induced by cisplatin in rats. Methods: The ARF rats were administered the Changkun Granules . Serum BUN and SCr of all the rats were measured and the renal morphology was evaluated. Results: Serum BUN level in the 'Changkun Granules' group was lower than the one in cisplatin group. ' Changkun Granules could also improve renal histology damage. Conclusion: The results indicated that'Changkun Granules' had certain protective effect on experimental ARF.

关 键 词：长坤冲剂 急性肾功能衰竭 顺铂 副作用 ARF 肾保护作用 

分 类 号：R277.525[医药卫生—中医学] R285.5