大黄提取物对急性肝衰大鼠肝性脑病的防治作用  

Preventive and Therapeutic Effects of Extract from Rheum pabnatum on Hepatic Encephalopathy in Rats with Acute Liver Failure

作　　者：张秋菊[1] 程惠娟[1] 王成永[1] 张长伟[1] 汪骏[1] 

机构地区：[1]安徽中医学院,合肥230038

出　　处：《中药材》2002年第8期573-575,共3页Journal of Chinese Medicinal Materials

摘　　要：目的:探讨大黄提取物对急性肝衰大鼠肝性脑病的防治作用及其机制。方法:用硫代乙酰胺(TAA)灌胃建立大鼠急性肝衰的肝性脑病模型,观察大黄提取物对肝性脑病大鼠的神经行为改变、神经病学测试、血氨浓度、血浆内毒素浓度和肝脏病理损伤的影响。结果:大黄提取物能明显改善肝性脑病大鼠的神经反射,降低大鼠肝性脑病的分期;显著降低血氨,血浆内毒素浓度,减轻肝脏病理损伤。结论:大黄提取物对TAA引起的大鼠肝性脑病有较好的防治作用,其作用机制与降低血氨、血浆内毒素浓度,保护肝细胞有关。Objective: To probe the preventive, therapeutic effect and the possible mechanism of extract from Rheum palmatum ( ERP) on hepatic encephalopathy(HE) in rats with acute liver failure. Methods: HE was induced by the administration of 300 mg thioracetamide per kg body weight by gavage on two consecutive days. The effects of ERP were observed on neurology test, serum ammonium, serum endotoxin and liver impairment. Results: ERP could improve rat neuro-reflexes, decrease the staging of HE and rat serum ammonium, endotoxin concentrations, and reduce the liver impairment. Conclusion: ERP significantly prevents and treats HE in rats with thioacetamide-induced acute liver failure.

关 键 词：大黄提取物 大黄 硫代乙酰胺 肝性脑病 药理学 急性肝功能衰竭 

分 类 号：R277.779[医药卫生—中医学] R285.5