中药有效成分防治骨性关节炎的研究进展  

Advances of active ingredients of traditional Chinese medicine in the prevention and treatment of osteoarthritis

作　　者：韩晗 张媛媛[1,2] 潘立 陈正东 薛漓轩 余伯阳 寇俊萍[1,2] HAN Han 1,2 ,ZHANG Yuanyuan 1,2 ,PAN Li 1,2 ,CHEN Zhengdong 1,2 ,XUE Lixuan 1,2 ,YU Boyang 1,2 ,KOU Junping 1,2(1 Jiangsu Key Laboratory of Traditional Chinese Medicine Evaluation and Translational Research; 2 School of Traditional Chinese Pharmacy,China Pharmaceutical University,Nanjing 211198,Chin)

机构地区：[1]中国药科大学江苏省中药评价与转化重点实验室,南京211198 [2]中国药科大学中药学院,南京211198

出　　处：《中国药科大学学报》2018年第3期279-285,共7页Journal of China Pharmaceutical University

摘　　要：骨性关节炎(osteoarthritis,OA)是临床上常见的慢性退行性关节疾病,其发病率随着年龄的增加逐渐上升,严重影响中老年患者的生活质量。现阶段对于OA的药物治疗如非甾体类抗炎药物(nonsteroidal anti-inflammatory drugs,NSAIDs)和镇痛药,虽能改善OA症状,但不能阻止OA的进展。中药有效成分在治疗OA疾病方面具有独特的优势。本文从中药有效成分抑制炎症相关因子的分泌、改善软骨基质合成及分解代谢失衡、抑制软骨细胞凋亡、促进软骨细胞增殖、调节雌激素水平等方面综述了近五年来国内外期刊报道的中药有效成分防治OA的研究进展,以期为OA的新药研发提供理论依据。Osteoarthritis（ OA）,a common chronic degenerative joint disease,rises gradually with age,which seriously affects the quality of life of middle-aged and elderly patients. Currently,the therapeutic medications such as nonsteroidal anti-inflammatory drugs（ NSAIDs） and analgesics might improve OA symptoms,but cannot prevent the development of OA. The active ingredients of traditional Chinese medicine（ TCM） have unique advantages in the treatment of OA. This article reviews the research progress of active ingredients of TCM in the prevention and treatment of OA reported by domestic and foreign journals in the past five years from the aspects of inhibition of the secretion of inflammation-related factors,improvement of cartilage matrix synthesis and catabolic imbalance,inhibition of chondrocyte apoptosis,promotion of chondrocyte proliferation,and regulation of estrogen levels,with an attempt to provide a theoretical basis for the development of new drugs for OA.

关 键 词：中药 骨性关节炎 作用机制 

分 类 号：R965[医药卫生—药理学]