ARTP诱变育种技术在尼莫克汀菌种选育中的应用  

Application of ARTP Mutation Technology in Breeding of nemadectin Strain

作　　者：刘瑞华 任启伟 陈仁瑞 蒋澜 阚显照[2] Liu Ruihua1, Ren Qiwei1, Chen Renrui2, Jiang Lan2, Kan Xianzhao2(1. The Xinyu Pharmaceutical Co., Ltd., Suzhou 234000： 2. College of Life Sciences, Anhui Normal University, Wuhu 241000, Chin)

机构地区：[1]新宇药业股份有限公司,安徽宿州234000 [2]安徽师范大学生命科学学院,安徽芜湖241000

出　　处：《广东化工》2018年第13期122-124,共3页Guangdong Chemical Industry

摘　　要：利用新型诱变技术提高尼莫克汀的发酵水平。利用ARTP诱变技术,处理尼莫克汀菌种S1-2-50,获得高产菌种S2-1-13,摇瓶效价提高25%。应用于60吨发酵罐生产,发酵水平与初始菌种相比大幅提高了35%。根据实验结果显示,ARTP诱变技术能够有效的提高尼莫克汀的发酵水平。To improve the fermentation level of nemadectin by new mutation technology. The ARTP mutation techology was used to treat the nemadectin S1-2-50. The high-yielding strain S2-1-13 was obtained with a 25 % increase in shake flask titer. Used in 60-tons fermentor production, the fermentation level increased by 35 % compared with the original strain. According to the experimental results, ARTP mutagenesis can effectively increase the fermentation level of nemadectin.

关 键 词：尼莫克汀 ARTP 诱交育种 

分 类 号：Q93[生物学—微生物学]