神经节苷脂与神经系统发育关系的研究进展  

Researchadvances of gangliosides in neural development

作　　者：陈飞[1,2] 吴美琴 刘建文[2] 颜崇淮[1] CHEN Fei;WU Meiqin;LIU Jianwen;YAN Chonghuai(MOE-Shanghai Key Laboratory of Children＇s Environmental Health,Xinhua Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;State Key Laboratory of Bioreactor Engineering and Shanghai Key Laboratory of New Drug Design,School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China)

机构地区：[1]上海交通大学医学院附属新华医院教育部和上海市环境与儿童健康重点实验室,中国上海200092 [2]华东理工大学药学院生物反应器国家重点实验室和上海市新药设计重点实验室,中国上海200237

出　　处：《教育生物学杂志》2018年第2期101-106,共6页Journal of Bio-education

摘　　要：神经节苷脂(ganglioside,GA)主要存在于神经系统中,是神经细胞表面主要分子决定簇。它不仅参与神经系统的发育和学习记忆等高级神经活动,还与一些由细菌、病毒以及自身免疫等因素引起的疾病密切相关。结合近些年的研究,就其与神经系统发育的关系予以综述。Gangliosides（ GA）,containing salivated glycosphingolipids（ GSLs）,abundant in the nervous system,are major molecular determinants on the surfaces of nerve cells. It is not only involved in the development of the nervous system and higher nervous activities,such as learning and memory,but also highly responsible for some diseases caused by bacteria,viruses,autoimmunity and other factors. Combined with recent years of researches,this paper reviews the changes in ganglioside expression during neural development and the roles in maintaining normal life activities.

关 键 词：神经节苷脂 神经系统 发育 

分 类 号：R338[医药卫生—人体生理学]