脑梗死后并发抑郁应用舒肝颗粒治疗的疗效观察  

Effects of Shugan Granule in the treatment of cerebral infarction followed depression

作　　者：刘晓溪 孙海民 李会敏[1] 史福平[1] 张杏红[1] 宋月平[1] LIU Xiaoxi;SUN Haimin;LI Huimin;SHI Fuping;ZHANG Xinghong;SONG Yueping(Departement of Neurology,Affiliated Hospital of Hebei Univercity,Baoding 071000,China)

机构地区：[1]河北大学附属医院神经内科,河北保定071000

出　　处：《医学研究与教育》2018年第3期30-34,共5页Medical Research and Education

基　　金：河北省重点研发计划项目(18277795D);河北省医学科学研究课题计划项目(ZD20140041)

摘　　要：目的观察脑梗死后并发抑郁患者应用舒肝颗粒治疗的临床疗效。方法将80例脑梗死后抑郁患者按机械抽样法随机分为2组,各40例。治疗组,在心理干预治疗的基础上给予舒肝颗粒1袋/次,2次/日;对照组只给予心理干预治疗。治疗时间均为60 d。应用汉密尔顿抑郁量表(hamilton depression scale,HAMD)对患者治疗前和治疗后60 d进行评估,日常生活能力评分应用日常生活活动量表(barther index,BI)评定,同时测定患者治疗前和治疗后的肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)和C-反应蛋白含量(C-reactive protein,CRP)。结果治疗组和对照组的有效率分别为85.0%和30.0%,2组差异有统计学意义(P<0.05)。治疗组和对照组治疗前的HAMD评分差异无统计学意义(P>0.05),治疗组治疗60 d后的HAMD评分较治疗前降低(P<0.05),对照组治疗60 d后HAMD评分较治疗前降低(P<0.05),治疗60 d后治疗组与对照组比较HAMD评分降低(P<0.05)。治疗组治疗后TNF-α和C-CRP明显低于对照组(P<0.05)。不良反应在2组均不明显。结论舒肝颗粒治疗脑梗死后并发抑郁治疗效果较好,不良反应不明显,因此在临床应用中安全性较高。Objective To evaluate the effects of Shugan Granule on cerebral infarction followed depression. Methods 80 patients with cerebral infarction fobllowed depression were randomly divided into two groups by mechanical sampling. 40 cases of the treatment group were treated with psychological intervention and combined with orally Shugan Granule 1 bag/time, 2 times a day. 40cases of the control group were only given psychological intervention. The treatment time was 60 d. The treatment effects were assessed using Hamilton anxiety scale（HAMD） before and after treatment at the 60 th day. Results The treatment group s effective rate of the and the control group s effective rate were respectively 85.0%（34/40） and 30.0%（12/40）, the difference was statistically significant between the two groups （ P〈 0.05）. The HAMD score before treatment showed no significant difference between the two groups[（28.10±3.42）vs（27.50±2.30）] （ P〉 0.05）, the score of the treatment group after treatment at days 60 was（6.35±3.05）, compared with prior treatment has statistically significant（ P〈 0.05）, the score of the control group after treatment at days 60 was （13.01±3.01）, compared with prior treatment has statistically significant（ P〈 0.05）, which indicated that there was statistically significant between the treatment group after treatment at 60th day and the control group （ P〈 0.05）. The levels of tumor necrosis factor-α（ TNF-α ） and C-reactive protein（CRP）in the treatment group decreased significantly than that in the controls （ P〈 0.05 ）. Neither group had significant adverse reactions. Conclusion Shugan Granule has positive treatment effects in patients with cerebral infarction followed depression. There are fewer adverse reactions, so there are high security in clinical applications.

关 键 词：脑梗死 抑郁 心理疗法 舒肝颗粒 肿瘤坏死因子-Α C-反应蛋白 

分 类 号：R54[医药卫生—心血管疾病]