埃索美拉唑与奥美拉唑治疗胃溃疡的疗效对比观察及价值分析  

Comparative Observation and Value Analysis of Esomeprazole and Omeprazole in the Treatment of Gastric Ulcer

作　　者：陈芳洁[1] 王秀敏[1] CHEN Fang-jie;WANG Xiu-min(Department of Gastroenterology,Anyang People＇s Hospital,Anyang Henan 455000,China)

机构地区：[1]安阳市人民医院消化科,河南安阳455000

出　　处：《药品评价》2018年第12期52-54,共3页Drug Evaluation

摘　　要：目的:比较埃索美拉唑与奥美拉唑在治疗胃溃疡方面的疗效以及临床应用价值。方法:将2016年5月—2017年5月来我院门诊就诊并诊断为胃溃疡的患者160例随机分为2组,分别为对照组和观察组,各80例,其中观察组采用埃索美拉唑、阿莫西林、克拉霉素的三联疗法进行治疗。对照组采用奥美拉唑、阿莫西林、克拉霉素的三联疗法进行治疗,根据治疗结果,比较分析2组药物的治疗效果差异。结果:对照组患者的总有效率为78.75%,明显低于观察组93.75%,(P<0.05)。2组患者治疗后不良反应发生率差别不明显,结果无统计学意义(P>0.05)。对照组患者治愈后一年内的复发率25%明显高于观察组8.75%,结果有统计学意义(P<0.05)。观察组患者的溃疡面愈合时间和完全治愈时间明显短于对照组患者,结果有统计学意义(P<0.05);结论:以埃索美拉唑为质子泵抑制剂的三联疗法在治疗胃溃疡方面有治愈率高、复发率低等特点,值得在临床上推广使用。Objective： To compare the efficacy and clinical value of esomeprazole and omeprazole in the treatment of gastric ulcers. Methods： 160 patients with gastric ulcers diagnosed in our hospital from May 2017 to May 2018 were randomly divided into two groups, the control group and the observation group, of which 80 of the observation group were treated with esomeprazole, Amoxicillin, clarithromycin triple therapy for treatment. 80 people in the control group were treated with omeprazole, amoxicillin and clarithromycin. According to the results of the treatment, the difference between the two groups was compared and analyzed. Results： The total effective rate of the control group was 78.75%, which was significantly lower than that of the observation group（93.75%, P〈0.05）. There was no significant difference in the incidence of side effects between the two groups after treatment, and the results were not statistically significant（P〉0.05）. In the control group, the recurrence rate（25%） was significantly higher than that in the observation group（8.75%） in one year after treatment, and the result was statistically significant（P〈0.05）. The healing time and complete cure time of the ulcer surface in the observation group were significantly shorter than those in the control group, and the results were statistically significant（P〈0.05）. Conclusion： The triple therapy with esomeprazole as proton pump inhibitor has high cure rate and low recurrence rate in the treatment of gastric ulcer. It is worth popularizing in clinical practice.

关 键 词：埃索美拉唑 奥美拉唑 胃溃疡 三联疗法 

分 类 号：R975.6[医药卫生—药品]