101例药源性睡眠障碍文献分析  

Literature analysis of 101 cases with drug-induced sleep disorder

作　　者：张东肃 蔡乐[1] 苏晔[1] 史红[1] 杨梅[1] 康怡 朱莹[1] ZHANG Dong-su;CAI Le;SU Ye;SHI Hong;YANG Mei;KANG Yi;ZHU Ying(Department of Pharmacy,Beijing Chaoyang Hospital Affiliated to Capital University of Medical Sciences,Beijing 100020,China)

机构地区：[1]首都医科大学附属北京朝阳医院药事部,北京100020

出　　处：《中国药物应用与监测》2018年第3期158-161,共4页Chinese Journal of Drug Application and Monitoring

摘　　要：目的:探讨各类药物导致药源性睡眠障碍的规律和特点,为临床合理用药提供参考。方法:检索中国期刊全文数据库(CNKI)(1979–2017年)、万方数据库(1990–2017年)和维普数据库(VIP)(1989–2017年)有关药物致睡眠障碍的文献资料,采用回顾性研究方法对符合纳入标准的68篇文献中报道的101例病例报告中患者基本情况、给药途径及发生时间、药品种类等情况进行统计分析。结果:101例药源性睡眠障碍患者中,男性患者多于女性患者,男女比例为1.24:1。青中年患者(20~59岁)报告例数较多,共计59例(58.42%)。不良反应发生以抗菌药物为主,共计35例(34.65%)。给药途径以口服给药为主共计66例(65.35%)。不良反应发生时间多在用药当天发生,共计62例(62.00%)。101例患者预后良好,痊愈、好转101例(100.00%)。结论:药源性睡眠障碍涉及药物种类较多,临床应提高对药源性睡眠障碍的认识,加强对高危人群及高危药物的预警防范。Objective： To explore the characteristics of sleep disorders caused by drugs in order to provide references for rational drug use in clinic. Methods： Literature on drug-induced sleep disorders were searched through databases including CNKI（1979 – 2017）, Wanfang database（1990 – 2017） and VIP database（1989 – 2017）. A total of 101 cases reported in 68 literature were enrolled and retrospectively anaylzed according to basic situation of patients, administration route, occurrence time of sleep disorder, kind of suspect drugs, etc. Results： Among the 101 cases, male patients were more than female patients, the ratio of male to female was 1.24 ： 1. Most reported cases（59 cases, 58.42%） were in middle age（20 – 59 years old）. Sleep disorders were mainly caused by antimicrobial agents（35 cases, 34.65%）. A total of 66 cases（65.35%） with drug-induced sleep disorders were orally administrated. And there were 62 cases（62.00%） developed sleep disorders on the first day of administration. All the 101 cases（100.00%） were fully recovery or improved. Conclusion： There were many kinds of drugs which could lead to sleep disorder. Clinical staff should be aware of drug-induced sleep disorders. For the high-risk population and the high-risk drugs, strengthened precautions must be taken against drug-induced sleep disorders.

关 键 词：药源性疾病 睡眠障碍 药品不良反应 

分 类 号：R969.3[医药卫生—药理学]