运动对肠道屏障和黏膜免疫稳态影响的研究进展  

Effect of Exercise on Intestinal Barrier Function and Mucosal Immunity Homeostasis

作　　者：吴嵽[1] 陈佩杰[1] 罗贝贝[1] WU Die;CHEN Pei-jie;LUO Bei-bei(Shanghai University of Sport,Shanghai 200438,China)

机构地区：[1]上海体育学院运动科学学院,上海200438

出　　处：《体育科学》2018年第6期67-75,共9页China Sport Science

基　　金：国家自然科学基金资助项目(31471135);上海市教委晨光计划(16CG57);上海市科委扬帆计划(17YF1418000);运动健身科技省部共建教育部重点实验室

摘　　要：肠道屏障和黏膜免疫稳态是机体抵御外来病原微生物入侵的重要防线。运动过程中血液重新分配,消化系统血液灌流量减少,肠道处于低氧环境,诱导转录因子低氧诱导因子(hypoxia-inducible factor,HIF)-1α持续表达,参与调节肠黏膜免疫稳态。相关研究证明,中小强度运动有助于肠黏膜免疫稳态的维持,而大强度运动损伤肠道屏障,破坏肠黏膜免疫稳态。通过回顾肠道屏障结构基础及黏膜免疫机能相关研究报道,综述不同强度运动对肠道屏障功能和黏膜免疫稳态的影响,进一步讨论HIF-1α在运动对肠道屏障功能和黏膜免疫稳态的调节中所起的关键作用,为运动与肠道屏障功能和黏膜免疫相关研究提供新思路。Intestinal barrier and mucosal immunity homeostasis are the vital defense against pathogen invasion.Exercise induces tissue blood flow redistribution,leading to hypoxia in gastrointestinal tract.Under hypoxic condition,hypoxia-inducible transcription factor（HIF）-1α is phosphorylated and stabilized,regulating intestinal mucosal immune homeostasis.Related studies have revealed that moderate exercise maintains mucosal immunity homeostasis,while heavy exercise causes intestinal barrier dysfunction.Therefore,we briefly introduce the intestinal barrier structure and mucosal immune system;review the effects of different intensities of exercise on intestinal barrier function and mucosal immunity homeostasis;further discuss the possible protective mechanism of HIF-1α.This review provides a new insight for exercise training,intestinal barrier function and mucosal immunity related research areas.

关 键 词：肠道屏障 黏膜免疫 运动 低氧诱导因子-1Α 

分 类 号：G804.5[文化科学—运动人体科学]