有氧运动联合参附注射液对心肌病心衰大鼠NT-proBNP的影响  

Effect of Aerobic Exercise Combined with Shenfu Injection on NT-proBNP in Rats with Cardiomyopathy-Induced Heart Failure

作　　者：胡思远 李欣春[2] 胡志希[2] 梁昊[2] HU Siyuan;LI Xinchun;HU Zhixi;LIANG Hao(Wuhan Sports University,Wuhan,Hubei 4300079,China;Hunan University of Chinese Medicine Changsha,Hunan 410208,China)

机构地区：[1]武汉体育学院,湖北武汉430079 [2]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2018年第6期641-644,共4页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金项目(81373550;81774208;81503627);湖南省大学生研究性学习和创新性实验计划项目(2016-298);湖南中医药大学青年教师科研基金(2015-32)

摘　　要：目的观察有氧运动联合参附注射液对心肌病心衰大鼠N末端脑钠素前体(NT-proBNP)的影响。方法 50只SD大鼠随机选取10只作为对照组,其余40只腹腔注射盐酸多柔比星建立心肌病心衰模型。造模成功后,将造模存活大鼠随机分为模型组、参附注射液组、有氧运动组、有氧运动联合参附注射液组,每组9只。以上各组分别用生理盐水、参附注射液、有氧运动、有氧运动联合参附注射液干预4周,用Elisa法检测NT-proBNP指标。结果成功复制心肌病心衰大鼠模型,有氧运动联合参附注射液组大鼠死亡率最低。模型组NT-proBNP水平较高,与其他各组比较差异有统计学意义(P<0.05);参附注射液组与有氧运动组NT-proBNP比较,差异无统计学意义(P>0.05);有氧运动联合参附注射液组NT-proBNP水平明显降低,与参附注射液组、有氧运动组比较差异有统计学意义(P<0.05)。结论参附注射液、有氧运动均能降低NT-proBNP水平,对心衰有较好疗效,且有氧运动联合参附注射液的效果最佳,提示有氧运动联合参附注射液治疗心衰的方法值得研究和推广应用。Objective To observe the effect of aerobic exercise combined with Shenfu injection on N-terminal pro brain natriuretic peptide （NT-proBNP） in rats with cardiomyopathy-induced heart failure. Methods The 50 SD rats were randomly selected 10 rats as the control group, and the others were built for the cardiomyopathy model by intraperitoneal injection of doxorubicin hydrochloride. After the model was successful, the model group was randomly divided into the model group, the Shenfu injection group, the aerobic exercise group and the aerobic exercise combined with the Shenfu injection group, 9 rats in each group. After 4 weeks intervention respectively with saline, Shenfu injection and aerobic exercise, NT-proBNP index was detected by Elisa method. Results Heart failure rats with cardiomyopathy were successfully established, aerobic exercise combined with Shenfu injection group showed the lowest mortality rate. The level of NT-proBNP in model group was higher than other groups, the difference was ststistically significant （P 〈0.05）. There was no significant difference of NT-proBNP between the Shenfu injection group and the aerobic exercise group （P〉0.05）. The level of NT-proBNP in aerobic exercise combined with aerobic exercise group which has a good effect （P〈0.05） on heart Conclusion failure, and Shenfu Shenfu aerobic njection group njection and was significantly lower than Shenfu injection group and aerobic exercise exercise combined with Shenfu could reduce the level of NT-proBNP, injection shows the best efficacy, which is worthy to be clinically popularized.

关 键 词：有氧运动 心衰 参附注射液 N末端脑钠素前体 

分 类 号：R256.2[医药卫生—中医内科学] R285.5[医药卫生—中医学]