中药穴位敷贴联合前列地尔治疗下肢动脉硬化闭塞症的临床研究  

Clinical Effect of Acupoint Application of Traditional Chinese Medicine Combined with Alprostadil in Treatment of Lower Extremity Arteriosclerosis Obliterans

作　　者：冯涛[1] 李晶[1] 郑殿宇 马震[1] FENG Tao;LI Jing;ZHENG Dianyu;MA Zhen(TCM Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang 830000,China)

机构地区：[1]新疆医科大学附属中医医院,新疆乌鲁木齐830000

出　　处：《湖南中医药大学学报》2018年第6期683-686,共4页Journal of Hunan University of Chinese Medicine

基　　金：新疆维吾尔自治区自然科学基金(2016D01C135)

摘　　要：目的探究中药穴位敷贴联合前列地尔治疗下肢动脉硬化闭塞症(arteriosclerosis obliterana,ASO)的临床疗效。方法选取符合病例选择标准的80例ASO患者按照随机原则分为观察组和对照组,每组各40例。对照组在常规治疗的基础上采用前列地尔加葡萄糖溶液静注,观察组在对照组的基础上加用中药穴位敷贴,两组患者均治疗8周。观察两组患者治疗后的临床疗效、不良反应,比较两组治疗前后的症状体征积分、踝肱指数(ankle brachial index,ABI)。结果观察组治疗后总有效率为92.5%,高于对照组的77.5%,差异有统计学意义(P<0.05);治疗后,两组患者的症状体征积分均较治疗前降低(P<0.05),且观察组低于对照组(P<0.05);治疗后,两组患者的ABI均较治疗前增高(P<0.05,P<0.01),且观察组高于对照组(P<0.05);所有患者未出现不良反应。结论中药穴位敷贴联合前列地尔治疗可改善ASO患者的临床症状体征、ABI,疗效确切,安全可靠。Objective To explore the clinical effect of acupoint application of Chinese medicine combined with alprostadil in the treatment of arteriosclerosis obliterana （ASO）. Methods 80 randomly divided into the observation group and the control group alprostadil plus glucose solution based on routine treatment. The patients with ASO were s with 40 cases in each group. observation group was treate elected as the subjects and were The control group was treated with d with acupoint application on the basis of the control group. The two groups were treated for 8 weeks. The clinical efficacy and adverse reactions of the two groups after treatment were observed. The scores of symptoms and signs and the ankle brachial index （ABI） of the two groups before and after treatment were compared. Results After treatment, the total effective rate of the observation group was 92.5%, which was higher than that （77.5%） in the control group, the difference was statistically significant （P〈0.05）; After treatment, the symptom scores of the two groups were lower than those before treatment （P〈0.05）, and the observation group was lower than the control group （P〈0.05）. After treatment, ABI of two groups were higher than that before treatment （P〈0.05, P〈0.01）, and the observation group was higher than that of the control group （P〈0.05）. There were no serious adverse reactions in all patients. Conclusion Acupoint application of Chinese medicine combined with alprostadil can improve the clinical symptoms and signs, and ABI of ASO patients, the curative effect is accurate, safe and reliable.

关 键 词：下肢动脉硬化闭塞症 中西结合 穴位敷贴 前列地尔 

分 类 号：R269[医药卫生—中西医结合] R246.2[医药卫生—中医外科学]