肾脏铜稳态平衡调控机制研究进展  

Progress on Regulation Mechanism of Copper Homeostasis in Kidney

作　　者：李鹤[1] 孙胜悦 黄元龙[1] 杨文艳[1,2] 杨连玉[1,2] LI He;SUN Sheng-yue;HUANG Yuan-long;YANG Wen-yan;YANG Lian-yu(College of Animal Science and Technology,Jilin Agricultural University,Changchun,Jilin,130118,China;Jilin Key Laboratory of Animal Nutrition and Feed Science,Changchun,Jilin,130118,China)

机构地区：[1]吉林农业大学动物科学技术学院,吉林长春130118 [2]吉林省动物营养与饲料科学重点实验室,吉林长春130118

出　　处：《动物医学进展》2018年第6期75-78,共4页Progress In Veterinary Medicine

基　　金：国家自然科学基金青年科学基金(31302002);吉林省自然科学基金(20150101075JC)

摘　　要：哺乳动物的生命活动过程中,几乎离不开铜和铁的氧化还原特性反应,并且铜常以Cu^(2+)的形式与其相关蛋白结合的形式作为一些功能性蛋白的辅基,同时铜结合蛋白的结构在其发挥生物学功能过程中具有重要作用。肾脏是铜排泄的器官,肾脏细胞内铜的吸收、储存、释放、转运对肾脏铜稳态很重要,肾脏铜稳态的失衡使肾脏线粒体结构发生断裂,肾脏细胞脱落导致肾脏排泄发生障碍。随着对肾脏铜转运因子与靶细胞器研究的逐步深入,论文综述了胞内的线粒体、高尔基体、胞浆分别与铜伴侣蛋白、铜转运蛋白的结合途径,阐明了铜转运蛋白(CTR1)的表达机制,铜离子转出蛋白(ATP7A)、铜离子转出蛋白(ATP7B)在高铜情况下的再分配机制,为揭示肾脏铜稳态机制奠定理论基础。In the process of mammalian life,it is almost inseparable from the redox properties of copper and iron.Copper is often used as a complementary group in the form of Cu＋ that associated with some related proteins,and the structures of copper-binding proteins play important roles in their biological function.The kidney is the organ of copper excretion.The absorption,storage,release,and transport of copper in the kidney cells are important for copper homeostasis in the kidney.The imbalance of copper homeostasis in the kidneys causes disruption of the mitochondrial structure in the kidneys,and the loss of renal cells leads to impaired renal excretion.With the study of the renal copper transporter and the target cells.this article reviewed the intracellular binding pathways of mitochondria,Golgi,and cytoplasm with copper chaperones and copper transporters,clarified the mechanism of copper transporter（CTR1）expression and the mechanism of redistribution of protein（ATP7A）and protein（ATP7B）under the high level of copper in order to reveal the theoretical basis of the renal copper homeostasis mechanism.

关 键 词：肾脏 铜稳态平衡 铜转运蛋白 铜伴侣蛋白 

分 类 号：S852.2[农业科学—基础兽医学]