缺血修饰性白蛋白与冠状动脉狭窄病变的相关性  

Relationship between ischemia-modified albumin and coronary stenosis

作　　者：范雅洁 郑阳[1] 徐阳[2] 韩拓 巩红 马维冬 刘晓唤 贾珊[1] 胡艳超[1] 张春艳[1] 张岩[1] 王聪霞[1] FAN Ya-jie;ZHENG Yang;XU Yang;HAN Tuo;GONG Hong;MA Wei-dong;LIU Xiao-huan;JIA Shan;HU Yan-chao;ZHANG Chun-yan;ZHANG Yan;WANG Cong-xia(Department of Cardiology,the Second Affiliated Hospital of Xi an Jiaotong University,Xi an 710004;Department of Clinical Laboratory,the Second Affiliated Hospital of Xi an Jiaotong University,Xi an 710004,China)

机构地区：[1]西安交通大学第二附属医院心血管内科,陕西西安710004 [2]西安交通大学第二附属医院检验科,陕西西安710004

出　　处：《西安交通大学学报（医学版）》2018年第4期459-462,478,共5页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：国家自然科学基金资助项目(No.81273878)~~

摘　　要：目的探讨缺血修饰性白蛋白(IMA)与非急性心肌梗死(MI)冠心病患者冠状动脉狭窄病变的关系。方法回顾性分析在西安交通大学第二附属医院行冠脉造影的345名患者的临床资料。根据造影结果,将研究对象分为冠脉病变组(232例)与对照组(113例),探讨IMA、IMA/血清白蛋白(IMAr)与冠脉狭窄病变发生的关系。结果 (1)冠脉病变组IMA、IMAr水平显著高于对照组(P<0.001);(2)单支病变组与多支病变组IMA、IMAr均显著高于对照组(P<0.05),而单只病变组与多支病变组之间IMA、IMAr差异无统计学意义(P>0.05);(3)ROC曲线分析显示,IMA、IMAr预测冠脉狭窄的灵敏度分别为64.4%、78.0%,曲线下面积分别为0.653、0.705(P<0.001);(4)多因素回归分析结果显示,IMAr是非MI冠心病患者的独立危险因素(OR=73.05,P<0.001)。结论 IMA、IMAr与冠脉狭窄密切相关,并对非MI患者冠脉狭窄有一定的预测价值。To investigate the relationship between ischemia-modified albumin （IMA） and coronary artery stenosis in patients without myocardial infarction.Methods For this study we consecutively enrolled 345 patients who received coronary angiography （CAG）. According to the results, the subjects were divided into coronary stenosis group （232 cases） and control group （113 cases） to investigate the the relationship of IMA and IMA/albumin （IMAr） with coronary stenosis.Results ① The levels of IMA and IMAr in coronary stenosis group were higher than those in control group （ P 〈0.001）. ② The IMA and IMAr were higher in single-branch and multi-branch lesion groups than in control group （ P 〈0.05）, whereas there was no significant difference between single-branch lesion group and multi-branch lesion group （ P 〉0.05）. ③ In receiver operating characteristics curve analysis, the sensitivity of IMA and IMAr was 64.4% and 78.0%, respectively （AUC： 0.653, 0.705, P 〈0.001） in predicting coronary stenosis. ④ Multivariate logistic regression analysis showed that IMAr was an independent risk factor for coronary stenosis in patients without myocardial infarction （ OR =73.05, P 〈0.001）.Conclusion IMA and IMAr are closely correlated with coronary stenosis and have a value in predicting coronary artery stenosis in patients without myocardial infarction.

关 键 词：缺血修饰性白蛋白 冠心病 冠状动脉造影 白蛋白 

分 类 号：R541.4[医药卫生—心血管疾病]