扶正消瘕方治疗胃癌前病变的临床疗效观察  

The curative effect of Fuzhengxiaojia decoction on precancerous lesions of gastric cancer

作　　者：孙涛[1,2] 刘德山[1,3] 朱玉[4] 周兰[2] 李昌玲[3] 姚诗清 汪超[2] 陈莉[2] SUN Tao;LIU De-shan;ZHU Yu;ZHOU Lan;LI Chang-ling;YAO Shi-qing;WANG Chao;CHEN Li(Clinical Medical College,Shandong University,Jinan 250012;Department of Traditional Chinese Medicine,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004;Department of Traditional Chinese Medicine,Qilu Hospital of Shandong University,Jinan 250012;Digestive Department,the First Affiliated Hospital of Bengbu Medical College,Bengbu 233004,China)

机构地区：[1]山东大学临床医学院,山东济南250012 [2]安徽蚌埠医学院第一附属医院中医科,安徽蚌埠233004 [3]山东大学齐鲁医院中医科,山东济南250012 [4]安徽蚌埠医学院第一附属医院消化科,安徽蚌埠233004

出　　处：《西安交通大学学报（医学版）》2018年第4期597-601,608,共6页Journal of Xi’an Jiaotong University（Medical Sciences）

基　　金：山东省中医药科技发展计划项目(No.2013-27);山东大学基本科研业务费资助项目(No.2014QLKY07)~~

摘　　要：目的观察扶正消瘕方治疗胃癌前病变(precancerous lesion of gastric cancer,PLGC)的疗效。方法选择我院PLGC患者44例,随机分为对照组和治疗组。对照组给予胃复春片口服4片/次,3次/d;治疗组在对照组基础上加服扶正消瘕方加减每日1剂,水煎服400mL。1个月为1个疗程,连服2个疗程。结果 2组治疗前的超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSHPx)、IgG、IgM和IgA无统计学差异(P>0.05)。治疗后,与对照组相比,治疗组的SOD(t=2.144,P=0.044)和GSH-Px(t=2.322,P=0.030)升高,MDA(t=3.096,P=0.005)、IgG(t=2.421,P=0.025)、IgM(t=3.377,P=0.003)和IgA(t=2.521,P=0.020)降低。治疗前2组中医主要症状积分无统计学差异(P>0.05);治疗后,与对照组相比,治疗组的中医主要症状饮食减少(t=3.924,P<0.001)、胃中嘈杂(t=4.161,P<0.001)和胃脘或胁肋胀(t=2.881,P<0.009)积分降低,总有效率增高(χ2=4.539,P=0.033)。结论胃复春片联合扶正消瘕方加减治疗PLGC较单纯中成药治疗有更好的疗效,与改善氧化还原及免疫球蛋白有关。Objective To observe the curative effect of Fuzhengxiaojia decoction on precancerous lesion of gastric cancer（PLGC）.Methods We randomly divided 44 patients with PLGC in our hospital into control group（n=22）and treatment group（n=22）.The control group was given4 Weifuchun tablets each time and three times per day and while the treatment group was given one Fuzhengxiaojia decoction of 400 mL besides the medication of the control group.They were treated for two courses,one course lasting for one month.Results Superoxide dismutase（SOD）,malondialdehyde（MDA）,glutathione peroxidase（GSH-Px）,IgG,IgM and IgA in the two groups had no significant differences before treatment（P〉0.05）.After treatment,compared with those in the control group,SOD（t=2.144,P=0.044）and GSH-Px（t=2.322,P=0.030）increased,while MDA（t=3.096,P=0.005）,IgG（t=2.421,P=0.025）,IgM（t=3.377,P=0.003）and IgA（t=2.521,P=0.020）decreased.The main symptom scores in the two groups did not significantly differ before treatment（P〈0.05）.After treatment,compared with those in the control group,the scores for main symptoms like reduced food intake（t=3.924,P〈0.001）,stomach noise（t=4.161,P〈0.001）and gastric or hypochondriac swelling（t=2.881,P〈0.009）decreased in the treatment group.The rate of effective cases was higher than that in the control group（χ2=4.539,P=0.033）.Conclusion The effect of Weifuchun combined with Fuzhengxiaojia prescriptions in treating PLGC is better than Weifuchun alone,which is related to improving redox and immunoglobulin.

关 键 词：扶正消瘕方 胃癌前病变 胃复春片 氧自由基 免疫球蛋白 

分 类 号：R285.5[医药卫生—中药学]