中药雷公藤的肝脏毒性及其个体易感性  

Hepatic toxicity and its individual susceptibility of Tripterygium Wilfordii

作　　者：杨非凡 王玉明[1] 董文颖[1] 李楠[1] 杨益 李遇伯[1] YANG Feifan;WANG Yuming;DONG Wenying;LI Nan;YANG Yi;LI Yubo(Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China)

机构地区：[1]天津中医药大学,天津300193

出　　处：《天津中医药大学学报》2018年第3期188-191,共4页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：天津市卫生和计划生育委员会中医中西医结合科研课题(2017102);国家自然科学基金面上项目(81573825)

摘　　要：中药安全性在近些年来越来越受到人们的重视,其毒性的机制及可能产生的不良反应逐渐被广大研究者进行深入研究。那么如何能够科学认知、早期发现和系统评价中药毒性的相对性、易感性和可控性就显得尤为重要。中药的毒性不是凭空说造的,而是通过长期大量的研究和总结中发现得到。经研究发现,毒性的影响因素众多,如毒性成分未知、机体特异性因素、免疫因素等等,往往可以通过辨证论治或不同药材配伍等方法来减轻药物的毒性。明确中药安全性研究现状和不足,提出新的研究策略,为合理评价中药安全性及临床安全用药提供思路。In recent years, the safety of traditional Chinese medicine has drawn more and more attention. The mechanism of its toxicity and possible adverse reactions has been gradually studied in-depth by the majority of researchers. Therefore, how to scientifically recognize, early discover and systematically evaluate the relativity,susceptibility and controllability of the toxicity of traditional Chinese medicine is particularly important. The toxicity of traditional Chinese medicine is not made out of thin air, but found through long-term large number of studies and summary. It has been found that there are many factors of toxicity, such as unknown toxicity components, specific factors of organism, immune factors, etc., which can be reduced by dialectical treatment of symptoms or compatibility of different medicinal materials. Clarify the present study situation and deficiency of Chinese medicine safety research and put forward a new research strategy, which provide ideas for rational evaluation of the safety of Chinese medicine and clinical safety medication.

关 键 词：雷公藤 肝脏毒性 个体易感性 

分 类 号：R285.5[医药卫生—中药学]