生血宁片治疗妊娠期缺铁性贫血疗效的Meta分析  

Therapeutic Efficacy of Shengxuening Tablets in the Treatment of Iron-deficiency Anemia during Pregnancy:A Meta-analysis

作　　者：陈帆 刘微微 刘巧艳[1] 曹世义[1] CHEN Fan1,LIU Weiwei2,LIU Qiaoyan1,CAO Shiyi1(1. School of Public Health,Tongji Medical College,Huazhong University of Science and Technology,Wuhan 430030,China;2. Dept. of Gynecology,HubeiProvince Maternal and Child Health Hospital,Wuhan 430070,Chin)

机构地区：[1]华中科技大学同济医学院公共卫生学院,武汉430030 [2]湖北省妇幼保健院妇产科,武汉430070

出　　处：《中国药房》2018年第12期1707-1710,共4页China Pharmacy

基　　金：国家中医药管理局资助项目(No.国中医药科2016ZX08)

摘　　要：目的:系统评价生血宁片治疗妊娠期缺铁性贫血的疗效,为临床提供循证参考。方法:计算机检索中国知网、万方、维普、PubMed等数据库中2008-2018年发表的关于生血宁片治疗妊娠期缺铁性贫血的临床随机对照试验(RCT),筛选文献、提取资料并采用改良后的Jadad评分量表评价纳入研究的质量,采用Stata 12.0软件进行Meta分析。结果:共纳入11项RCT,合计1 617例患者。生血宁片的总有效率均显著高于硫酸亚铁[OR=8.73,95%CI(2.96,25.69),P<0.05]、琥珀酸亚铁[OR=1.86,95%CI(1.04,3.33),P<0.05]和膳食调理[OR=3.43,95%CI(2.08,5.66),P<0.05],差异均有统计学意义。结论:生血宁片治疗妊娠期缺铁性贫血的疗效显著优于常规补铁剂。OBJECTIVE：To evaluate therapeutic efficacy of Shengxuening tablets in the treatment of iron-deficiency anemia during pregnancy, so as to provide evidence for clinical decisions. METHODS： Retrieved from CNKI,Wanfang,VIP and PubMed,clinical randomized controlled trials（RCTs）about Shengxuening tablets in the treatment of iron-deficiency anemia during pregnancy were collected during 2008-2018. After screening literatures and extracted information, the literature quality was evaluated by using improved Jadad scale. Meta-analyses was performed by using Stata 12.0 software. RESULTS：A total of 11 RCTs were included,inulving 1 617 patients. Total response rate of Shengxuening tablets was significantly higher than those of ferrous sulfate [OR=8.73,95%CI（2.964,25.69）,P〈0.05],ferrous succinate [OR=1.86,95%CI（1.04,3.33）,P〈0.05] and dietory conditioning [OR=3.43,95% CI（2.08,5.66）,P〈0.05],with statistical significance. CONCLUSIONS：Therapeutic efficacy of Shengxuening tablets is significantly better than that of routine iron supplements in the treatment of iron-deficiency anemia during pregnancy.

关 键 词：生血宁片 妊娠期缺铁性贫血 随机对照试验 META分析 

分 类 号：R973.3[医药卫生—药品]