SLC39A6基因表达与膀胱癌的关系研究  

Expression of SLC39A6 in Hnman Bladder Cancer

作　　者：苏娟[1] Su Juan(Department of Gastroenterology,Renmin Hospital of Wuhan University,Hubei 430060,China)

机构地区：[1]武汉大学人民医院消化内科,430060

出　　处：《医学研究杂志》2018年第6期35-38,共4页Journal of Medical Research

基　　金：湖北省自然科学基金资助项目(2012FFA096)

摘　　要：目的探讨SLC39A6基因在膀胱癌中的表达情况及其临床意义。方法采用荧光定量PCR检测54例膀胱癌患者手术切除的病理标本中膀胱癌组织和相应的癌旁正常组织中SLC39A6基因的表达情况,并分析膀胱癌组织中SLC39A6基因的表达量变化与肿瘤的分级和临床病理分期之间的关系。结果 SLC39A6基因在癌旁正常组织中呈低表达,相对表达量为0.353±0.057;在膀胱癌组织中高表达,相对表达量为0.592±0.069,两组SLC39A6基因相对表达量比较差异有统计学意义(P<0.05)。在膀胱癌组织中,SLC39A6基因相对表达量与癌组织的临床分期、分化程度呈正相关(P=0.000)。结论人膀胱癌组织中SLC39A6基因的表达水平较正常膀胱组织增高,并可能促进了膀胱癌细胞的侵袭和转移。Objective To investigate the expression of SLC39 A6 in hnman bladder cancer and its clinical significance. Methods Real-time quantitative PCR was used to detect the expression of SLC39 A6 in para-carcinoma tissue and bladder cancer tissue,and all the tissues were derived from the pathological specimens of 54 cases of bladder cancer patients. Besides,we will analyse the correlation between the expression of SLC39 A6 and the histological grade and clinical pathologic staging of bladder cancer. Results The expression level of SLC39 A6 in para-carcinoma tissue and bladder cancer tissue were respectively 0. 353 ± 0. 057 and 0. 592 ± 0. 069. The result of comparison between two groups shows that the expression level of SLC39 A6 in bladder cancer tissue is significantly higher than that in para-carcinoma tissue,so there is a significant difference between two groups（ P〈0.05）. In addition,the expression level of of SLC39 A6 in bladder cancer tissue were significantly increased with the increasing of histological grades and clinical pathologic staging（ P = 0. 000）. Conclusion The expression of SLC39 A6 in human bladder cancer tissue is up-regulated compared with normal human bladder tissue,and it may promote the invasiveness and metastasis of bladder cancer.

关 键 词：SLC39A6 膀胱癌 分期 

分 类 号：R692.9[医药卫生—泌尿科学]