视神经脊髓炎谱系疾病合并症与临床特征的关系  

Relationship of Comorbidities and Clinical Manifestations of Neuromyelitis Optica Spectrum Disorders

作　　者：孔丽娜 韩永良[1] 罗琦[1] 曾春[1] 王静杰[1] 李咏梅[1] KONG Lina;HAN Yongliang;LUO Qi;ZENG Chun;WANG Jingjie;LI Yongmei(Department of Radiology,the First Affiliated Hospital of Chongqing Medical University,Chongqing 400016,China)

机构地区：[1]重庆医科大学附属第一医院放射科,重庆400016

出　　处：《中国医学影像学杂志》2018年第2期81-85,共5页Chinese Journal of Medical Imaging

基　　金：国家自然科学基金(81371523);重庆市卫计委医学科研重点课题(2016ZDXM002)

摘　　要：目的探讨视神经脊髓炎谱系疾病合并症与临床特征的关系。资料与方法回顾性分析2012年10月—2017年8月于重庆医科大学附属第一医院神经内科住院的63例视神经脊髓炎谱系疾病(NMOSD)患者的临床资料,分析其临床特征与合并症的关系。结果 (1)52例NMOSD患者患有合并症,以高脂血症、2型糖尿病、感染等常见,其中≥3种20例、2种12例、1种20例,无合并症11例。(2)≥3种合并症组与1种合并症组相比,仅首发年龄增加,但差异无统计学意义(P>0.05),首发到确诊间隔、病程、复发次数差异无统计学意义(P>0.05)。(3)≥3种合并症组与其余组比较,首发年龄增加,首发到确诊间隔及病程缩短,但差异无统计学意义(P>0.05)。结论 NMOSD患者合并症种类多样,并可能同时合并多种合并症,且首发年龄越大,其合并症数量越多,首发到确诊及病程越短。因此提高对NMOSD合并症的认识,避免将合并症与NMOSD的症状混淆而延误诊断,有利于NMOSD患者的早期诊断和及时治疗。Purpose To explore the relationship between the comorbidities and clinical manifestations of neuromyelitis optica spectrum disorders（NMOSD）. Materials and Methods Clinical materials of 63 NMOSD patients hospitalized in the department of neurology of the First Affiliated Hospital of Chongqing Medical University from October 2012 to August 2017 were collected, and relationship of comorbidities and clinical manifestations were analyzed. Results（1）Fifty-two patients suffered from complications and the common ones were hyperlipemia, type 2 diabetes, and infection, among over or equal to 20 of three kinds, 12 of two kinds and 20 of one kinds and 11 unaffected.（2） When comparing group of ≥3 complications with one complication, only the age of primary onset increased but the difference was of no statistical significance（P〈0.05）. Difference of intervals from onset to diagnosis, course of disease and recurrence was of no statistical significance（P〈0.05）.（3） When comparing group of ≥3 complications with remaining groups, the age of initial onset increased and intervals from onset to confirmation were shortened. However, the difference was of no statistical significance（P〈0.05）. Conclusion Patients with NMOSD have a variety of comorbidities and may combine with multiple comorbidities at the same time. The older the onset age is, the more the complications are and shorter intervals from onset to confirmation and course of disease is. Therefore, enhancement of recognition on complications can avoid delayed diagnosis caused by mixture of complications with NMOSD, which is in favor of early diagnosis and timely treatment of NMOSD patients.

关 键 词：视神经脊髓炎 视神经脊髓炎谱系疾病 磁共振成像 诊断 鉴别 

分 类 号：R445.2[医药卫生—影像医学与核医学] R744[医药卫生—诊断学]