九香虫提取物的抗疲劳和补肾壮阳活性评价  

Evaluation of Anti-fatigue and Aphrodisiac Activity of Extract from Aspongopus chinensis

作　　者：李娟[1,2,3] 张一唱[3] 崔光红 马晓晶[1,2] 陈科力[3] 黄璐琦[1,2] Li Juan;Zhang Yichang;Cui Guanghong;Ma Xiaojing;Chen Keli;Huang Luqi(Post-doctoral Research Station,China Academy of Chinese Medical Sciences,Beijing 100700,China;National Resource Center for Chinese Materia Medica,China Academy of Chinese Medical Sciences,Beijing 100700,China;Hubei University of Chinese Medicine,Wuhan 430065,China)

机构地区：[1]中国中医科学院博士后科研流动站,北京100700 [2]中国中医科学院中药资源中心,北京100700 [3]湖北中医药大学,武汉430065

出　　处：《中南民族大学学报（自然科学版）》2018年第2期45-48,共4页Journal of South-Central University for Nationalities：Natural Science Edition

基　　金：中国博士后科学基金资助项目(2016M601237);湖北省教育厅科学研究计划资助项目(Q20172009);湖北省自然科学基金资助项目(2017CFB397)

摘　　要：目的:评价九香虫提取物的抗疲劳和补肾壮阳活性.方法:以九香虫水提取物低、高剂量组(1.4,7.0 g·kg^(-1))小鼠灌胃给药15 d后,测定了小鼠的力竭游泳时间、血清尿素氮和血乳酸含量等.皮下注射氢化可的松建立了小鼠的肾阳虚模型,九香虫提取物低、高剂量组连续灌胃30 d,检测了小鼠胸腺、脾脏、肾上腺、睾丸、精囊腺等脏器系数,以及交配能力(捕捉潜伏期、捕捉率、交配潜伏期、交配率等).结果:九香虫提取物高剂量组能显著降低小鼠血清乳酸和尿素含量,延长力竭游泳时间,具有明显的抗疲劳作用.高剂量组还能显著增加肾阳虚小鼠的免疫器官、睾丸和附性器官的脏器系数,提高交配能力,具有明显的补肾壮阳作用.结论:九香虫提取物具有明显的抗疲劳和补肾壮阳作用.Objective： To evaluate the anti-fatigue and aphrodisiac activities of the extract from Aspongopus chinensis.Method： After low and high doses of extracts of Aspongopus chinensis（ 1.4,7.0 g·kg^-1） were intragastrically administered for 15 days,the loaded swimming time,serum urea nitrogen and lactic acid were measured. Kidney Yang deficiency mice model was established by subcutaneous administration of hydrocortisone. The viscera coefficients of thymus,spleen,adrenal gland,testis,seminal vesicle,and the mating ability（ capture latency,capture rate,mating latency,mating rate） were measured after the two groups of mice were treated by gavage for 30 consecutive days. Result： High dose group showed significant anti-fatigue activity,as evidenced by the decrease of the content of serum lactic acid and urea,and the increase of the loaded swimming time. In addition,the high dose group also showed significant aphrodisiac activity by increasing the viscera coefficient of the immune organs,testicles and accessory sex organs of Yang deficiency mice,and improving the mating ability. Conclusion： The extracts of Aspongopus chinensis had apparent anti-fatigue and aphrodisiac effect.

关 键 词：九香虫 水提取物 抗疲劳 补肾壮阳 

分 类 号：Q956[生物学—动物学]