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作 者:郑娟善 丁保安[1] ZHENG Juanshan;DING Baoan(College of Agriculture and Animal Husbandry,Qinghai University,Xining 810016,China)
机构地区:[1]青海大学农牧学院,西宁810016
出 处:《中国畜牧兽医》2018年第6期1571-1579,共9页China Animal Husbandry & Veterinary Medicine
基 金:国家自然科学基金地区科学基金项目(31160463);青海省科技厅国际合作项目(2015-HZ-801)
摘 要:β-1,3/1,6-葡聚糖作为一种潜在的免疫调节佐剂,普遍存在于真菌、酵母及海藻中,主要由以β-1,3键构成的线性骨架为主链,以及以高度分支的β-1,6键为侧链组成,其特殊的键结方式和分子内氢键使其形成螺旋形的分子结构,这种独特的构型很容易被免疫系统识别,从而发挥免疫功能。β-1,3/1,6-葡聚糖是第一个被发现的具有免疫活性的葡聚糖,其作为一种生物性免疫调节佐剂,对免疫系统和疫苗免疫效果具有调节作用。由于β-1,3/1,6-葡聚糖具有生物活性高、热力低等性能,可作为脂肪替代品、功能因子、膳食纤维等广泛应用于医药开发、保健食品、动物饲养等行业中,是一种值得研究和开发的功能性饲料添加剂。作者在介绍β-1,3/1,6-葡聚糖的来源、作用机理和生物活性的基础上,重点论述了其添加在畜禽日粮中对畜禽肠道的发育、生产性能、免疫功能的影响,同时对其应用时应注意的问题进行了阐述,旨在为β-1,3/1,6-葡聚糖在畜禽日粮中的应用奠定理论基础。As a potential immuno regulatory adjuvant,β-1,3/1,6-glucans are commonly found in fungi,yeasts and seaweeds.It consists of a linear skeleton of theβ-1,3 key chain as main backbone and a highly branchedβ-1,6 bond as a side chain.Due to its special molecular bonding and intramolecular hydrogen bonding,it forms a spiral molecular structure.This unique configuration is easily accepted by the immune system and exerts its immunity features.β-1,3/1,6 glucan is the first one that has been found to be immunologically active dextran,creating a new chapter in the application of dextran as an immune enhancer.Studies have shown thatβ-1,3/1,6-glucan,as a biological immunomo regulatory adjuvant,has a regulatory effect on immune system and the efficiency of vaccination.It has higher biological activity,lower caloric value and other aspects,which can be widely used in the fields of medicine,health food and animal husbandry as a fat substitutes,functional factors and dietary fiber making it a worthy endeavor to research and develop as a functional feed additive.Based on the origin,mechanism and biological activity ofβ-1,3/1,6-glucan,the production performance and immune function of livestock and poultry was summarized in this paper,and the usage in livestock and poultry diets was analyzed hoping to provide fundamental basis for the application ofβ-1,3/1,6-glucan in diets of livestock and poultry.
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