甘草及其提取物对豚鼠β-肾上腺素受体耐受性的保护作用  

Protective Effect of Glycyrrhlza uralensis Fisch and Its Extracts on the Chronic Desensitization of β-Adrenoceptors in Guinea Pigs

作　　者：赵树进[1] 吴红霞[1] 曹永舒[1] 

机构地区：[1]河南医科大学,郑州450052

出　　处：《中国中药杂志》1991年第6期370-371,共2页China Journal of Chinese Materia Medica

摘　　要：以组织胺引喘试验和放射性配基结合分析法证明,豚鼠经反复应用异丙肾上腺素可见β-肾上腺素受体反应性降低和肺组织β-受体数目减少。腹腔注射甘草水煎剂或甘草提取物Lx66可以防止上述变化,而腹腔注射甘草次酸或甘草水煎剂灌胃则无此种保护作用。Histamine-induced wheezing test in conjunction with radioligand binding assay showed that after long-term administration of isoprenaline the reactivity and R, value(total receptor binding sites)of β-adrenoceptors in the lung tissue of guinea pigs were reduced. The decoction of Glycyrrhiza uralensis Fisch or its extractive LX_(?) given intraperitoneally could prevent these changes, hut the decoction per os or glycyrrhetinic acid given intraperitoneally could not.

关 键 词：Β受体激动剂 耐受性 甘草 

分 类 号：R285.5[医药卫生—中药学]