7-氯-4-羟基二氢化茚的合成研究  

Research on Synthesis of 7-Chloro-4-hydroxy-2,3-dihydro-1H-indene

作　　者：赵长阔[1] 王先恒 袁智 曹颖 徐浪 ZHAO Chang-kuo;WANG Xian-heng;YUAN Zhi;CAO Ying;XU Lang(School of Pharmacy,Zunyi Medical University,Zunyi,Guizhou 563099,China)

机构地区：[1]遵义医学院药学院,贵州遵义563099

出　　处：《浙江化工》2018年第6期18-21,共4页Zhejiang Chemical Industry

基　　金：贵州省科技厅项目(黔科合支撑[2017]2844)

摘　　要：以对氯苯酚为起始原料,依次通过酚羟基酯化、酰基重排后亲电取代得到茚环、酮羰基还原三步骤反应得到7-氯-4-羟基二氢化茚1,总收率46.2%。Starting from ρ-chlorophenol, 7-chloro-4-hydroxy-2,3-dihydro-1 H-indene 1 was synthesized through 3 steps, in turn with phenolic hydroxyl esterification, acyl group rearrangement following by electrophilic substitution to form indene ring, reduction of ketone carbonyl group. Total yield of the target compound reached 46.2%

关 键 词：对氯苯酚 7-氯-4-羟基二氢化茚 合成 高收率 

分 类 号：TQ460.1[化学工程—制药化工]