南瓜籽抗前列腺增生化学成分研究  

Chemical Constituents of Pumpkin Seeds against Benign Prostatic Hyperplasia

作　　者：李千会 徐德平[1] LI Qian-hui;XU De-ping(School of Food Science and Technology,Jiangnan University,Wuxi 214122,China)

机构地区：[1]江南大学食品学院,无锡214122

出　　处：《天然产物研究与开发》2018年第6期978-982,共5页Natural Product Research and Development

摘　　要：本文研究了南瓜籽抗前列腺增生活性及功效成分。南瓜籽乙醇回流提取,经石油醚萃取,硅胶柱、ODS反向柱层析柱分离,用核磁共振方法鉴定结构。结果表明:南瓜籽醇提石油醚萃取相经硅胶柱层析氯仿∶甲醇(8∶2、7∶3)梯度洗脱物对小鼠前列腺增生活性的抑制效果最明显,再经ODS柱分离,得到了三个单体化合物,分别为3-甲酸-1,4-环己二烯-2-十一烷酸甲酯(1),3-甲酸-1,4-环己二烯-2-十一烯酸甲酯(2),2-十一烯酸甲酯-3-十一烷酸-环己-1,4-二烯酯(3)。化合物1~3为首次从南瓜籽中分离得到的酯类物质。This study was aimed to investigate whether the ethanol extract of petroleum ether phase from Pumpkin Seeds had impactson the prostatic hyperplasia in mice. The results showed that 80% and 90% ethanol extract of petroleum ether phase from Pumpkin Seeds was the most sensitive part on the prostatic hyperplasia activity inhibition. Then three pure 1,4-cyclohexenyl ester monomer compounds were further separated from this part by ODS column： 3-carboxylic acid-1,4-cyclohexadiene-2-undecanoate,3-carboxylic acid-1,4-cyclohexadiene-2-undecylenic acid methyl ester,Methyl2-undecenoate-3-undecanoate-cyclohexyl-1,4-dienyl ester. These three compounds are anti-prostate active site separation,identification of esters from Pumpkin Seeds. Whether they have anti-prostatic hyperplasia active ingredients,but also need further study.

关 键 词：南瓜籽 抗前列腺增生 分离 鉴定 

分 类 号：R284.2[医药卫生—中药学] Q946[医药卫生—中医学]