左旋氨氯地平联合天麻钩藤颗粒对高血压病人NT-ProBNP与颈部血管内膜厚度的影响  

Effects of Levamlodipine and Tianma Gouteng Granules on the NT-ProBNP and Carotid Vascular Intima Thickness in Patients with Hypertension

作　　者：杭亮 张永刚 田慧娟 Hang Liang;Zhang Yonggang;Tian Huijuan(Yulin Hospital of Traditional Chinese Medicine,Yulin 719000,Shaanxi,China)

机构地区：[1]榆林市中医医院,陕西榆林719000

出　　处：《中西医结合心脑血管病杂志》2018年第10期1327-1330,共4页Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease

摘　　要：目的探讨左旋氨氯地平联合天麻钩藤颗粒对高血压病人N末端B型利钠肽原(NT-ProBNP)与颈部血管内膜厚度的影响方法选取2015年2月—2017年2月我院接诊的94例高血压病人,采用随机数字表法分为观察组和对照组,每组47例。在常规治疗基础上,对照组给予苯磺酸左旋氨氯地平片治疗,观察组给予苯磺酸左旋氨氯地平片联合天麻钩藤颗粒治疗,均连续治疗8周。比较两组治疗前后血压、血浆NT-ProBNP、颈动脉内膜中层厚度(IMT)以及内皮依赖性血管舒张功能(FMD)的变化,并比较两组临床疗效。结果治疗后,两组收缩压(SBP)、舒张压(DBP)较治疗前均显著降低(P<0.05),观察组SBP、DBP明显低于对照组(P<0.05);治疗后,两组血浆NT-ProBNP较治疗前均显著减少(P<0.05),观察组血浆NT-ProBNP水平明显低于对照组(P<0.05);治疗后,两组IMT较治疗前均明显降低,FMD明显升高(P<0.05),观察组IMT明显低于对照组,FMD明显高于对照组(P<0.05);观察组临床疗效总有效率明显高于对照组(93.62%与70.21%,P<0.05)。结论高血压病人应用左旋氨氯地平联合天麻钩藤颗粒降压效果显著,且有助于降低血浆NT-ProBNP及IMT的表达。Objective To study the effects of levamlodipine and Tianma Gouteng granules （TGG） on the N-terminal type B natriuretic peptide （NT-ProBNP） and carotid vascular intima thickness in patients with hypertension. Methods Ninety-four patients with hy-pertension from February 2015 to February 2017 in our hospital were selected and randomly divided into two groups：control group （n=47） treated with levamlodipine besylate tablets,and observation group （ n=47） treated with levamlodipine and TGG in the basis of routine treatment for 8 weeks. The changes of blood pressure,plasma NT-ProBNP,carotid intima-media thickness （IMT） and endothelium dependent vasodilatation （FMD） were observed before and after treatment,and the clinical efficacy was compared. Results After treatment,the systolic blood pressure （SBP） and diastolic blood pressure （DBP） in two groups were significantly lower than that before treatment （ P〈0.05）,which were significantly lower in observation group than that in control group（ P〈0.05）. The plasma NT-ProB-NP levels in two groups were significantly lower than that before treatment（P〈0.05）,which was significantly lower in observation group than that in control group （ P〈0.05）. The IMT in two groups were significantly lower than that before treatment,and FMD signif-icantly increased （ P〈0.05）. The total effective rate in observation group was significantly higher than that in control group （93.62% vs 70.21% , P〈0.05）. Conclusion The levamlodipine and TGG has a significant antihypertensive effect in patients with hypertension, and it’s helpful to decrease the expression of plasma NT-ProBNP and IMT.

关 键 词：高血压 左旋氨氯地平 天麻钩藤颗粒 N末端B型利钠肽原 颈动脉内膜中层厚度 内皮依赖性血管舒张功能 

分 类 号：R544.1[医药卫生—心血管疾病] R289.5[医药卫生—内科学]