HLA-G在人类早期胚胎中的表达及应用价值  

Study on the Expression of HLA-G in Human Embryo and Its Applicative Value

作　　者：罗平[1] 沈开元[1] 黄彦妮[1] LUO Ping;SHEN Kaiyuan;HUANG Yanni(Reproductive Medicine Center,Liuzhou People＇s Hospital,Liuzhou 545006,China)

机构地区：[1]柳州市人民医院生殖医学科,广西柳州545006

出　　处：《医学综述》2018年第11期2104-2109,共6页Medical Recapitulate

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(Z20170677)

摘　　要：人类白细胞抗原(HLA)G能表达于人类胚胎滋养层细胞,并参与妊娠期免疫调控。HLA-G可通过调节细胞因子释放来诱导免疫耐受性的产生,调控滋养层细胞的侵入能力并且促使子宫螺旋动脉血管的重塑,促进胚胎成功着床和维持妊娠。HLA-G在人类卵母细胞及早期胚胎2细胞至囊胚阶段均有表达,并与胚胎分化程度相关;分泌可溶性HLA-G的胚胎在体外受精-胚胎移植中的临床妊娠率和种植率较高,胚胎培养上清液中可检测到HLA-G,含量受检测方法、灵敏度等因素影响;HLA-G结合形态学评分可更好地预测胚胎发育潜能,有望成为胚胎质量评估的可靠生化指标。Human leukocyte antigen（HLA）-G can express in human embryonic trophoblast cells and participate in the pregnancy immunization.HLA-G regulates the immune tolerance through stimulating cytokines release and trophoblast cell invasion ability,which can promote the remodeling of the arterial vessels,embryo implantation and pregnancy maintenance.The expression of HLA-G is detected in human oocyte and early embryo cell to blastocyst stage;it＇ s usually thought to be connected with embryonic differentiation degree.There are reports that the early cleave stage embryos,which could secrete soluble HLA-G,usually have a higher clinical pregnancy and implantation rate.HLA-G can be detected in embryo culture supernatant,but is often limited by detection method and reagent sensitivity.Generally,the HLA-G detection combined with morphological method can realize better prediction of the embryonic development potential,and it is expected to become a reliable biochemical indicator of embryo quality assessment.

关 键 词：人类白细胞抗原G 早期胚胎 培养上清液 体外受精-胚胎移植 

分 类 号：R715.5[医药卫生—妇产科学]