糖尿病视网膜病变伴高尿酸血症患者血清IL-1β、TNF-α检测意义  

The importance of serum IL-1β,TNF-α in diabetic retinopathy patients with hyperuricemia

作　　者：游慧 陈方[1] 李恒[1] 周游[2] YOU Hui;CHEN Fang;LI Heng;ZHOU You(Department of Ophthalmology;Department of Clinical Laboratory,Central Hospital of Suining,Suining,Sichuan 629000,China)

机构地区：[1]遂宁市中心医院眼科,四川遂宁629000 [2]遂宁市中心医院检验科,四川遂宁629000

出　　处：《国际检验医学杂志》2018年第13期1578-1581,共4页International Journal of Laboratory Medicine

基　　金：四川省卫生计划生育委员会科研课题(17PJ067)

摘　　要：目的分析糖尿病视网膜病变(DR)伴有高尿酸血症(HUA)患者体内炎症标志物水平,探讨DR与HUA的关系。方法选择该院2016年1月至2017年6月收治的DR患者190例为研究对象,根据尿酸(UA)水平分为糖尿病视网膜病变伴高尿酸血症组(HUDR组)95例、无高尿酸糖尿病视网膜病变组(DR组)95例,另选择同期Ⅱ型糖尿病患者(T2DM组)、健康体检者(HC组)作为对照。采用酶联免疫吸附试验法(ELISA)检测血清白细胞介素1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平,并进行统计学分析。结果各组间IL-1β、TNF-α水平比较,差异有统计学意义(P<0.05),其中HUDR组IL-1β、TNF-α水平明显高于DR组、T2DM组、HC组,差异有统计学意义(P<0.05);HUDR组患者增殖性DR为42.1%,显著高于DR组(27.4%),差异有统计学意义(P=0.033);HUDR患者血清UA与IL-1β、TNF-α水平呈显著性正相关(分别为r=0.356,P=0.000;r=0.660,P=0.000);Logistic回归分析显示UA(OR:1.857,95%CI:1.123~3.229)、IL-1β(OR:2.124,95%CI:1.336~3.715)、TNF-α(OR:1.673,95%CI:1.108~2.275)均是DR的独立危险因素。结论 HUDR患者血清IL-1β、TNF-α水平明显升高,HUA可能促进DR进展,是该病的独立危险因素。Objective To detected the levels of inflammatory markers in diabetic retinopathy（DR）patients with hyperuricemia（HUA）,and to investigated the relationship between diabetic retinopathy and hyperuricemia.Methods 190 DR patients were enrolled in to our study at January 2016 to June 2017,patients were divided into group of diabetic retinopathy with hyperuricemia（HUDR group）and group of diabetic retinopathy（DR group）according to level of serum UA,and selected diabetes mellitus patient（DM group）and health person（HC group）as control group.Detected serum interleukin 1β（IL-1β）and tumor necrosis factor-α（TNF-α）levels of participants and statistical analysis.Results The IL-1βand TNF-αlevels have significant difference between HUDR group,DR group,DM group and HC group,the difference was statistically significant（P〈0.05）;Among them,the levels of IL-1β、TNF-αin HUDR group was significantly higher than that of DR group,DM group and HC group,and the difference was statistically significant（P〈0.05）.The proportion of proliferative retinopathy in group HUDR was 42.1%,was significantly higher DR group which was 27.4%,the difference was statistically significant（P=0.033）.Serum UA level was positively corrected to IL-1β（r=0.356,P=0.000）and TNF-α（r=0.660,P=0.000）levels of HUDR patients.Logistic regression analysis reveal that UA（OR：1.857,95%CI：1.123-3.229）,IL-1β（OR：2.124,95%CI：1.336-3.715）and TNF-α（OR：1.673,95%CI：1.108-2.275）were independent risk factors of diabetic retinopathy.Conclusion There are higher levels of IL-1βand TNF-αin diabetic retinopathy patients with hyperuricemia,hyperuricemia may promote the progression of diabetic retinopathy and hyperuricemia is an independent risk factor of the disease.

关 键 词：糖尿病视网膜病变 高尿酸血症 白细胞介素1Β 肿瘤坏死因子-Α 

分 类 号：R587.1[医药卫生—内分泌]