前列腺阻力指数与冠状动脉粥样硬化性心脏病危险因素相关性研究  

Correlation between prostatic resistive index and risk factors of coronary atherosclerotic heart disease

作　　者：李臻[1] 叶纯华[1] 王康儿[1] 周卸来[1] 周进 LI Zhen;YE Chun-Hua;WANG Kang-er;ZHOU Xie-lai;ZHOU Jin(Department of Urology,The Affiliated Hospital of Hangzhou Normal University,Hangzhou 310015,China)

机构地区：[1]杭州师范大学附属医院泌尿外科,浙江杭州310015

出　　处：《健康研究》2018年第3期241-245,共5页Health Research

摘　　要：目的探讨良性前列腺增生(benign prostatic hyperplasia,BPH)患者前列腺阻力指数(prostatic resistive index,PRI)与冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease,CAD)的危险因素间的相关性。方法根据是否伴有CAD,将156例BPH患者分为I组和II组,选择同期门诊男性体检者为NC组。统计三组观察对象的空腹血糖(BG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、甘油三酯(TG)、总胆固醇(TC)、前列腺特异性抗原(PSA)、前列腺阻力指数(PRI)、前列腺体积(Vp)、体重指数(BMI)、国际前列腺症状评分(IPSS)以及CAD危险因素,包括高血压病(HP)、2型糖尿病(T2DM)、代谢综合征(Met S)、吸烟,对上述各组测量数据和PRI进行相关性及回归分析。结果I、II组的TG、TC、PSA、Vp、PRI、IPSS水平显著高于NC组,II组的TG、TC、PSA、BG、Vp、PRI水平显著高于I组;差异均有统计学意义(均P<0.05)。I、II组的PRI水平与年龄、LDL-C、TG、TC、PSA、BG、Vp、IPSS呈正相关,与HDL-C呈负相关,均有统计学意义(P<0.05)。回归分析显示,两组PRI水平和BG、Vp、Met S、吸烟具有显著相关性(P<0.05)。结论BPH患者PRI水平与CAD危险因素中的代谢综合征和吸烟密切相关,BPH和CAD的发生发展可能存在共同的病理生理机制。Objective To investigate the correlation between prostate resistance index（PRI）and risk factors of coronary atherosclerotic heart disease（CAD）in benign prostatic hyperplasia（BPH）.Methods 156 BPH patients were firstly divided into two groups,namely,group I（patients with CAD）and group II（（patients without CAD）.Meanwhile,88health volunteers from the outpatient department were chosen as the normal control（NC）group.The fasting blood glucose,high-density lipoprotein cholesterol（HDL-C）,low-density lipoprotein cholesterol（LDL-C）,triglyceride（TG）,total cholesterol（TC）,prostate specific antigen（PSA）,prostatic resistance index（PRI）,prostate volume（V_P）,body mass index（BMI）,international prostate symptom score（IPSS）,and risk factors of CAD（hypertension,type 2 diabetes,metabolic syndrome,smoking）were analyzed.The correlation and regression analysis between the above data and PRI were made.Results The levels of TG,TC,PSA,V_P,PRI and IPSS in group I and II were higher than those in NC group（P〈0.05）,The levels of TG、TC、PSA、BG、V_P、PRI in group II were higher than those in group I（P〈0.05）.The PRI levels in group I and II were positively correlated with age,LDL-C,TG,TC,PSA,BG,V_Pand IPSS,and negatively correlated with HDL-C（P〈0.05）.Regression analysis showed that the PRI levels of the two groups were significantly correlated with BG,V_P,metabolic syndrome and smoking（P〈0.05）.Conclusions The level of PRI in BPH patients is closely related to the metabolic syndrome and smoking in CAD risk factors.There may be a common pathophysiological mechanism in the occurrence and development of BPH and CAD.

关 键 词：良性前列腺增生 冠状动脉粥样硬化性心脏病 阻力指数 危险因素 

分 类 号：R69[医药卫生—泌尿科学]