雌激素联合复方紫草油治疗对糖尿病大鼠烫伤创面愈合的影响  

Healing Effect of Combined Treatment of Estrogen and Compound Radix Arnebiae Oil on the Scald Wound of Diabetic Rats

作　　者：吴健[1] 周美英[1] 史旭锋 武岳[1] Wu Jian;Zhou Meiying;Shi Xufeng;Wu Yue(Department of Burns,Ganau Provincial Hospital,Lanzhou 730000,China)

机构地区：[1]甘肃省人民医院烧伤科,兰州730000

出　　处：《世界中医药》2018年第5期1218-1221,共4页World Chinese Medicine

基　　金：甘肃省自然科学基金(1606RJZA155);甘肃省卫生行业科研计划项目(GSWSKY2015-03)

摘　　要：目的:探讨雌激素联合复方紫草油治疗对糖尿病大鼠烫伤创面愈合的影响。方法:将40只雄性SD大鼠随机分为空白组、模型组、雌激素组、复方紫草油组、雌激素联合复方紫草油组等5组;除空白组外,各组大鼠均建立糖尿病模型,成模后在所有大鼠背部造成深Ⅱ度烫伤。空白组与模型组不采取任何治疗,各观察组以相应的药物治疗。于伤后第1、8、15、22天检测各组大鼠创面愈合率、血糖及血清转化生长因子β1(TGF-β1)、血管内皮生长因子(VEGF)的表达,第22天行创面组织病理学观察并作病理评分。结果:与空白组比较,模型组大鼠创面愈合率显著降低、血糖明显升高,TGF-β1、VEGF含量显著降低,病理评分显著升高,差异有统计学意义(P<0.05);与模型组比较,各观察组大鼠创面愈合率明显升高、血糖明显降低,TGF-β1、VEGF含量显著升高,病理评分明显降低,差异有统计学意义(P<0.05)。结论:雌激素和复方紫草油可以促进糖尿病大鼠烫伤创面的愈合,且雌激素与复方紫草油联合用药对糖尿病大鼠烫伤创面愈合具有协同作用。Objective：To explore the effect of the burn wound healing in rats with diabetes by the combined treatment of estrogen and compound Radix Arnebiae Oil. Methods ： A total of 40 male SD rats were divided randomly into 5 groups, inclduing blank group, model group, estrogen group, Compound Radix Arnebiae Oii group, combined estrogen and Compound Radix Arnebiae Oil group. Except the blank group, the others were established the diabetes model. After the success of the model building, the whole rats were caused deep Ⅱ degree burn in the back. Apart from the blank group and the model group, each treatment group was trea-ted by the appropriate treatment methods. The wound healing rate and blood glucose of each rat was observed, and the expression of TGF-[31and VEGF in 1, 8, 15, 22 days real-time were detected. The wound tissue pathology of each rat was observed and made pathological grades. Results ： Compared with the blank group, rat wound healing rate of the model group was significantly reduced, and the blood sugar level increased significantly. The level of TGF-[31and VEGF decreased significantly, and the pathological grades rise significantly （ P 〈 0. 05 ）. Compared with the model group, the rat wound healing rate of each treatment group was obvi-ously higher, and the blood sugar level was significantly lower. The TGF-131and VEGF were significantly higher, and the patholog-ical score significantly reduced （ P 〈 0. 05 ）. Conclusion ： The estrogen and the Compound Radix Arnebiae Oil can promote the healing of burn wound on diabetic rats and play a role of collaborative work.

关 键 词：糖尿病创伤 雌激素 复方紫草油 愈合 

分 类 号：R242[医药卫生—中医临床基础]