扶正泻肝方治疗早期原发性肝癌患者疗效及对免疫功能影响  

Clinical Research of Fuzheng Xiegan Decoction in the Treatment of Primary Hepatic Carcinoma

作　　者：叶颖[1] 宋雅楠[1] 张莉君[1] 张遂亮[1] 庄菊花 何赛飞 夏伟[1] YE Ying;SONG Yanan;ZHANG Lijun;ZHANG Suiliang;ZHUANG Juhua;HE Saifei;XIA Wei(The Seventh People＇s Hospital Affiliated of Shanghai University of Traditional Chinese Medicine,Shanghai 200137,China)

机构地区：[1]上海中医药大学附属第七人民医院,上海200137

出　　处：《云南中医学院学报》2018年第1期34-37,共4页Journal of Yunnan University of Traditional Chinese Medicine

基　　金：国家自然科学基金(81703791);上海市浦东新区卫生系统重点学科群建设项目(PWZxq2014-12)

摘　　要：目的研究扶正泻肝方治疗原发性肝癌疗效及对患者免疫功能影响。方法研究对象选取40例早期原发性肝癌患者,均给予扶正泻肝方治疗3个月,比较治疗前后患者的肿瘤指标、肝功能指标、KPS评分、疼痛评分、免疫功能指标、中医证候积分等水平。结果治疗后,患者AFP值明显低于治疗前,AFP、ALT、AST、TBIL、DBIL均明显低于治疗前,TP水平明显高于治疗前,CD3^+、CD4^+水平及CD4^+/CD8^+比值均明显高于治疗前,CD8^+明显低于治疗前(P<0.01),KPS评分提高率为80.0%,此外,疼痛缓解率为85.0%,各临床症状改善的有效率均大于60%.结论扶正泻肝方治疗原发性肝癌临床疗效明显,尤其可减轻早期伴癌痛患者疼痛程度,改善患者免疫功能,促进生活质量恢复。Objective To study the effect of Fuzheng Xiegan decoction on the treatment of primary liver cancer and its immune function. Methods The subjects were 40 PHC patients in our hospital from October 2016 to June 2017, were treated with Fuzheng Xiegan decoction for 3 months. Tumor index, liver function index, KPS scores, pain degree, immune function index and traditional Chinese medicine（ TCM） syndrome scores were detected before and after the treatment. Results After treatment, AFP, ALT, AST, TBIL and DBIL in patients were significantly lower than those before treatment, and TP levels were significantly higher than before treatment, the levels of CD3＋, CD4＋and CD4＋/CD8＋were significantly higher than those before treatment, CD8＋was significantly lower than those before treatment（ P〈0.01）. The improvement rate of KPS score was 80.0%. In addition, the pain relief rate was 85.0%. The effective rates of all clinical symptoms were all over 60%.Conclusion Fuzheng Xiegan decoction treatment of primary liver cancer clinical significant effect, in particular, can reduce the early pain associated with cancer pain patients, improve immune function and promote the quality of life recovery.

关 键 词：扶正泻肝方 原发性肝癌 疼痛 

分 类 号：R273[医药卫生—中西医结合]