黄花蒿中1个新的香豆素苷类化合物  

A new coumarin glycoside isolated from Artemisia annua

作　　者：王倩[1,2] 侯国梅 李丹毅 李占林[1,2] WANG Qian;HOU Guo-mei;LI Dan-yi;LI Zhan-lin(Key Laboratory of Structure-Based Drug Design and Discovery,Ministry of Education,Shenyang Pharmaceutical University,Shenyang 110016,China;School of Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 11 O016,China)

机构地区：[1]沈阳药科大学基于靶点的药物设计与研究教育部重点实验室,辽宁沈阳110016 [2]沈阳药科大学中药学院,辽宁沈阳110016

出　　处：《中草药》2018年第13期2953-2958,共6页Chinese Traditional and Herbal Drugs

摘　　要：目的研究黄花蒿Artemisia annua全草大极性部位的化学成分。方法采用Sephadex LH-20柱色谱、硅胶柱色谱、ODS柱色谱和制备薄层色谱等方法进行分离纯化,根据波谱数据确定化合物的结构。结果从黄花蒿70%乙醇冷浸提取物的甲醇可溶部位中共分离得到14个化合物,分别鉴定为黄花蒿苷A(1)、东莨菪苷(2)、2,4-二羟基-6-甲氧基苯乙酮-4-O-β-D-吡喃葡萄糖苷(3)、咖啡酸甲酯(4)、水杨酸(5)、阿魏酸(6)、香草酸(7)、2,4-二羟基-6-甲氧基苯乙酮(8)、高圣草酚(9)、棕鳞矢车菊黄酮素(10)、penduletin(11)、甲氧基寿菊素(12)、圣草酚(13)和(R)-15,16-didehydrocoriolic acid(14)。结论化合物1为未见文献报道的新香豆素苷;化合物14为首次从蒿属植物中分离得到;化合物9为首次从黄花蒿中得到。Objective To study the chemical constituents with high polarity from the whole herb of Artemisia annua. Methods The constituents were isolated and purified by column chromatography on Sephadex LH-20, silica gel, ODS, and preparative TLC. The structures were elucidated by the analysis of the spectroscopic data. Results Fourteen compounds were obtained from the methanol soluble fraction of the 70% ethanol extract of A. annua by maceration at room temperature and identified as artemisiannuside A（1）, scopolin（2）, 2,4-dihydroxy-6-methoxyacetophenone-4-O-β-D-glucopyranoside（3）, methyl caffeate（4）, salicylic acid（5）, ferulic acid（6）, vanillic acid（7）, 2,4-dihydroxy-6-methoxyacetophenone（8）, homoeriodictyol（9）, jaceidin（10）, penduletin（11）, axillarin（12）, eriodictyol（13）, and（R）-15,16-didehydrocoriolic acid（14）, respectively. Conclusion Compound 1 is a new acylated coumarin glycoside. Compound 14 is isolated from the Artemisia genus for the first time and compound 9 is firstly isolated from A. annua.

关 键 词：黄花蒿 香豆素 黄酮类 黄花蒿苷A 高圣草酚 

分 类 号：R284.1[医药卫生—中药学]