中药防治奥沙利铂神经毒性的作用及机制研究进展  

Progress research on effect and mechanism of Chinese materia medica preventing oxaliplatin-induced neurotoxicity

作　　者：苏晓琳[1] 王江威 王长福 姜海[1] 赵婉[1] 杨炳友[1] 匡海学[1] 王秋红 SU Xiao-lin;WANG Jiang-wei;WANG Chang-fu;JIANG Hai;ZHAO Wan;YANG Bing-you;KUANG Hai-xue;WANG Qiu-hong(Heilongjiang Provincial Key Laboratory of Traditional Chinese Medicine and Effective Substance Basis of Natural Medicine,Key Laboratory of Basis and Application Research of North Medicine,Ministry of Education,Heilongjiang University of Chinese Medicine,Harbin 150040,China;Department of Chinese Medicine,Guangdong Pharmaceutical University,Guangzhou 510006,China)

机构地区：[1]黑龙江中医药大学教育部北药基础与应用研究重点实验室黑龙江省中药及天然药物药效物质基础研究重点实验室,黑龙江哈尔滨150040 [2]广东药科大学中药学院,广东广州510006

出　　处：《中草药》2018年第13期3148-3152,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81773904;81473351);黑龙江中医药大学科研基金项目(201720)

摘　　要：奥沙利铂是第3代铂类抗肿瘤药物,具有疗效好、抗癌谱广泛等优点。但周围神经病变是其主要的剂量限制性毒性,影响患者的治疗进程和生活质量。以中医理论为指导的益气活血、温阳通络等传统中药在治疗此症上取得一定进展。从中药复方及活性成分两方面对国内外研究进展予以综述,为临床医师治疗奥沙利铂神经毒性提供依据。Oxaliplatin is the third generation of platinum antitumor drugs, which has the advantages of good efficacy, broad anticancer spectrum and so on. However, peripheral neurotoxicity is the main dose limiting toxicity, which affects not only its clinical application but also the quality of patients＇ life. According to Chinese medicine theory, some progress has been made in the treatment of this disease by using the traditional herb with invigorating qi and activating blood and warming yang for removing obstruction in collaterals. This article summarizes the literatures in domestic and foreign countries from the aspects of Chinese prescription and active ingredients, which provides basis for clinicians to treat the neurotoxicity of oxaliplatin.

关 键 词：奥沙利铂 神经毒性 发病机制 中医药 防治方法 

分 类 号：R285[医药卫生—中药学]