蟾酥化学成分及其人工合成的研究进展  

Research progress on chemical constituents and artificial synthesis of Bufonis Venenum

作　　者：孙崇峰 范圣此 罗毅 孟兆青 徐晶晶 SUN Chong-feng;FAN Sheng-ci;LUO Yi;MENG Zhao-qing;XU Jing-jing(Shandong Hongjitang Pharmaceutical Co.,Ltd.,Jinan 250103,China)

机构地区：[1]山东宏济堂制药集团股份有限公司,山东济南250103

出　　处：《中草药》2018年第13期3183-3192,共10页Chinese Traditional and Herbal Drugs

摘　　要：蟾酥为我国传统名贵中药,其化学成分复杂,具有广泛的药理活性。蟾酥的化学成分主要包括蟾蜍内酯类、吲哚类生物碱、甾醇类及其他类化合物。现代药理学研究表明,蟾酥具有抗肿瘤、强心、抗炎、局麻、镇痛等多种药理活性。对近年来蟾酥化学成分、药理活性及其人工合成等方面的研究进展进行综述,以期为蟾酥的物质基础研究、药效机制阐释及其开发利用提供参考。Bufonis Venenum, as a precious Chinese materia medica, has complex chemical constituents and has been widely used in clinical treatment with significant effects. The chemical constituents in Bufonis Venenum mainly included bufadienolides, indole alkaloids, and steroids, etc. Modern pharmacological research has demonstrated its antitumor, cardiac, anti-inflammatory, and narcotic analgesic, etc. This paper reviewed the chemical constituents, pharmacological activity, and artificial synthesis of Bufonis Venenum, providing theoretical reference for material basic research, pharmacodynamic mechanism interpretation, development, and utilization.

关 键 词：蟾酥 蟾蜍内酯类 吲哚类生物碱 抗肿瘤 强心 抗炎 人工合成 

分 类 号：R282.74[医药卫生—中药学]