竹叶椒中酰胺类化学成分研究  

Chemical constituents of amides from Zanthoxylum planispinum

作　　者：苏光耀[1] 王奎武[1] SU Guang-yao;WANG Kui-wu(School of Food Science and Biotechnology,Zhejiang Gongshang University,Hangzhou 310018,China)

机构地区：[1]浙江工商大学食品与生物工程学院,浙江杭州310018

出　　处：《中草药》2018年第14期3213-3216,共4页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金面上项目(31170701);浙江省教育厅科研项目(Y201534531)

摘　　要：目的研究竹叶椒Zanthoxylum planispinum的化学成分。方法采用硅胶柱色谱、Sephadex LH-20凝胶柱色谱、制备高效液相色谱等技术进行分离纯化,通过理化性质、核磁共振和质谱等光谱数据鉴定化合物的结构。结果从竹叶椒的甲醇提取物中分离得到7个酰胺类化合物,分别鉴定为(2E,7E,9E)-N-isobutyl-6,11-dioxo-2,7,9-dodecatrienamide(1)、armatamide(2)、pellitorine(3)、lanyuamide I(4)、tetrahydro-bungeanool(5)、hydroxy-γ-isosanshool(6)、dihydrobungeanool(7)。结论化合物1为新的链状不饱和脂肪酸酰胺,命名为竹叶椒素,化合物2~7均为首次从该植物中分离得到。Objective To study the chemical constituents of Zanthoxylum planispinum. Methods The compounds were isolated and purified by repeated silica gel column chromatography, Sephadex LH-20 gel column chromatography, and preparative HPLC. Their chemical structures were identified on the basis of physico-chemical properties and spectral analysis. Results Seven amides were isolated and elucidated as（2 E, 7 E, 9 E）-N-isobutyl-6,11-dioxo-2,7,9-dodecatrienamide（1）, armatamide（2）, pellitorine（3）, lanyuamide I（4）, tetrahydro-bungeanool（5）, hydroxy-γ-isosanshool（6）, and dihydrobungeanool（7）. Conclusion Compound 1 is a new unsaturated alkylamide named planispinamide, and compounds 2—7 are obtained from this plant for the first time.

关 键 词：竹叶椒 酰胺 竹叶椒素 armatamide pellitorine dihydrobungeanool 

分 类 号：R284.1[医药卫生—中药学]