男性尖锐湿疣患者人乳头瘤病毒感染状况分析  

Analysis of human papiilomavirus infection in male patients with condyloma acuminatum

作　　者：陈光辉[1] 赵静[1] 艾予蜀[1] 刘德军[1] Chen Guanghui;Zhao Jing;Ai Yushu;Liu Dejun(Department of Clinical Laboratory,Helnan Provincial People＇s Hospital,Zhengzhou 450003,Chin)

机构地区：[1]河南省人民医院检验科,郑州450003

出　　处：《中华传染病杂志》2018年第5期277-279,共3页Chinese Journal of Infectious Diseases

基　　金：河南省卫计委医学科技攻关项目（201602231）

摘　　要：目的探讨男性尖锐湿疣患者人乳头瘤病毒（human papillomavirus, HPV）感染及其基因型的分布状况。方法2015年3月至2017年9月河南省人民医院确诊的男性尖锐湿疣患者332例。通过PCR扩增后进行导流杂交，利用基因芯片对患者尖锐湿疣组织进行HPV DNA分型检测。统计学分析采用χ^2检验。结果332例男性尖锐湿疣患者中，HPV阳性239例，阳性率为71.99%（95%CI： 67.16%～76.82%）。检测37个亚型中，除HPV-26、45、69、70亚型外，其他亚型均有检出，其中HPV-6亚型阳性率最高，占39.46%（95%CI： 34.20%～44.72%），其次为HPV-11亚型，占22.59%（95%CI： 18.09%～27.09%），比较差异有统计学意义（χ^2＝22.070，P〈0.05）。239例HPV阳性者中，单一感染158例，其中低危型139例，与高危型比较差异有统计学意义（χ^2＝182.3，P〈0.05）；多重感染81例，其中混合型55例（混合型与低危型比较，χ^2＝32.241，P〈0.05；混合型与高危型比较，χ^2＝60.201，P〈0.05）。尖锐湿疣患者主要分布于20～29岁年龄组，其次为30～39岁年龄组。结论男性尖锐湿疣患者HPV感染的基因型主要为低危型HPV-6、HPV-11亚型，单一感染较为常见，年龄主要集中于20～29岁。ObjectiveTo explore human papillomavirus （HPV） infection and genotype distribution in male patients with condyloma acuminatum （CA）.MethodsTotally 332 male patients with CA were enrolled from March 2015 to September 2017 at Henan Provincial People′s Hospital. By means of flow-through hybridization after polymerase chain reaction （PCR）, the wart tissue HPV DNA genotypes were detected by gene chip. χ^2 test was used to perform statistical analysis.ResultsAmong 332 male CA patients, 239 was positive for HPV with the positive rate of 71.99% （95%CI： 67.16%-76.82%）. A total of 37 kinds of genotypes, except for genotypes 26, 45, 69, 70, the others were all detected. The positive rate of genotype 6 was the highest in all detected genotypes （39.46%, 95%CI： 34.20%-44.72%） and the second one was genotype 11 （22.59%, 95%CI： 18.09%-27.09%）, and the difference was significant （χ^2=22.070, P〈0.05）. Among 239 HPV-positive CA patients, 158 were single infection and 139 were low-risk genotype （low-risk vs hight risk genotype： χ^2=182.3, P〈0.05）, and 81 were multiple infection and 55 were mixed genotype （mixed vs low-risk genotype： χ^2=32.241, P〈0.05; mixed vs high-risk genotype： χ^2=60.201, P〈0.05）. The CA patients mainly distributed in those aged 20 to 29 years, followed by those aged 30 to 39 years.ConclusionsThe genotypes of HPV infection in male patients with CA are mainly low-risk genotypes 6 and 11. Single infection is common, and the age of patients mainly distributes among 20 to 29 years old.

关 键 词：尖锐湿疣 男性 人乳头瘤病毒 

分 类 号：R752.53[医药卫生—皮肤病学与性病学]