sST2与Treg数量及冠状动脉病变程度的相关性  

Relationship between expression of soluble growth stimulating express gene 2 and regulatory T cells and coronary artery lesions

作　　者：何非[1] 盛建龙[1] 王晓晨[1] 胡广全[1] 王凯[1] 许邦龙[1] 程婧 HE Fei;SHENG Jian-long;WANG Xiao-chen;HU Guang-quan;WANG Kai;XU Bang-long;CHENG Jing(Department of Cardiology,the Second Affiliate Hospital of Anhui Medical University,Hefei,Anhui 230601;School of Nursing,Anhui University of Chinese Medicine,Hefei,Anhui 230038,China)

机构地区：[1]安徽医科大学第二附属医院心血管内科,安徽合肥230601 [2]安徽中医药大学护理学院,安徽合肥230038

出　　处：《热带医学杂志》2018年第7期913-918,共6页Journal of Tropical Medicine

基　　金：安徽省卫生计生委科研计划项目(全科医学临床科研课题;2016QK017);安徽省高校自然基金重点项目(KJ2018A0284);安徽省自然科学基金(1808085QH285)

摘　　要：目的探讨冠心病患者外周血清中可溶性生长刺激表达因子2(s ST2)水平及其与调节性T细胞(Treg)数量及冠脉病变严重程度的关系。方法连续入选初次接受冠状动脉造影检查的102例患者作为研究对象,按照冠状动脉造影结果分为非冠心病组(Non-CAD组,n=50)和冠心病组(CAD组,n=52)。测定外周血Treg数量和s ST2水平,Gensini积分评价冠状动脉病变严重程度,并进行统计学分析。结果与Non-CAD组相比,CAD组外周血Treg百分比显著降低(t=13.931,P<0.001),s ST2水平显著升高(t=11.978,P<0.001)。随着冠脉病变血管数的增加,外周血s ST2水平随之升高(F=63.183,P<0.001)。血清s ST2水平与Treg数量(r=-0.827,P<0.001)和高密度脂蛋白水平(r=-0.349,P<0.001)呈负相关,与Gensini积分(r=0.836,P<0.001)和体重指数(r=0.226,P=0.022)呈正相关。逐步多元回归分析表明,s ST2与Treg呈负相关(P<0.001),Gensini积分呈正相关(P<0.001)。结论冠心病患者外周血s ST2水平明显升高,与冠脉病变严重程度呈正相关,与Treg呈负相关,是冠脉病变严重程度的预测因子。Objective To investigate the relationship between circulating soluble growth stimulating express gene 2（s ST2）concentrations and the number of regulatory T cell（Treg）and the severity of coronary artery disease in patients underwent first-time angiography for suspected coronary artery disease（CAD）.Methods 102 consecutive patients were enrolled and divided into Non-CAD or CAD group according to the results of coronary angiography.Serum s ST2 concentrations were measured by ELISA.Circulating Treg number was determined by a flow cytometry.Associations of s ST2 with Treg and angiographic indexes of the severity of CAD（i.e.,number of diseased vessels and modified Gensini score）were estimated.Results s ST2 levels in patients with angiographically confirmed CAD were significantly higher than those with normal coronary arteries（t=11.978,P〈0.001）.Statistically significant correlations were observed between serum s ST2 level and Treg percentage（r=-0.827,P〈0.001）,high density lipoprotein（r=-0.349,P〈0.001）,body mass index（r=0.226,P=0.022）,and Gensini score（r=0.836,P〈0.001）.Using multivariate analysis,s ST2 level was independently associated with Treg percentage and Gensini score（P〈0.001）.Conclusion Serum s ST2 levels were significantly higher in patients with CAD.s ST2 levels were correlated negatively with Treg percentage and positively with Gensini score.Further clinical studies are needed to confirm the use of s ST2 as a biomarker for the detection of CAD.

关 键 词：冠状动脉粥样硬化性心脏病 调节性T细胞 可溶性ST2 冠状动脉造影 

分 类 号：R541.4[医药卫生—心血管疾病]