2008-2017年广州市登革热疫情流行趋势  

Epidemic trend of dengue fever in Guangzhou city from 2008 to 2017

作　　者：陆剑云[1] 陈宗遒[1] 马蒙蒙 蔡锐彬[2] 苏文哲[1] 李意兰[1] 马钰[1] 张周斌[1] 杨智聪[1] LU Jian-yun;CHEN Zong-qiu;MA Meng-meng;CAI Rui-bin;SU Wen-zhe;LI Yi-lan;MA Yu;ZHANG Zhou-bin;YANG Zhi-cong(Guangzhou Center for Diseases Control and Prevention,Guangzhou,Gnangdong 510440;The First Affiliated Hospital,Sun Yat-sen University,Guangzhou,Guangdong 510080,China)

机构地区：[1]广州市疾病预防控制中心,广东广州510440 [2]中山大学附属第一医院,广东广州510080

出　　处：《热带医学杂志》2018年第7期973-976,985,共5页Journal of Tropical Medicine

基　　金：国家自然科学基金(81273139);广东省自然科学基金(S2013010013637;2015A030313784);广州市医学重点学科建设项目(2017-2019-04);广州市卫生局一般引导项目(2015A011056;20151A011060)

摘　　要：目的分析2008-2017年广州登革热流行趋势,为制订防控策略提供依据。方法通过国家传染病监测信息报告管理系统收集病例信息,对每起登革热暴发疫情均开展现场流行病学调查并完成调查处置报告。对收集的疫情资料进行描述性分析,并对2008-2012年和2013-2017年疫情资料分组,对比分析疫情规模、持续时间、波及范围、暴发强度、病毒型别等方面的变化趋势。结果相比2008-2012年,2013-2017年广州市登革热总体疫情规模和年发病率呈上升趋势,输入疫情持续上升,本地疫情上升迅猛且疫情持续时间明显延长,本地疫情波及范围从2008-2012年波及的7个区59个街镇扩大到全部12个区和97.1%(165/170)的街镇,疫情强度从局部暴发规模上升到多次出现全市流行规模,此外,重症死亡病例增多,本地疫情的病毒型别也从4种血清型散发出现进展为1型和2型病毒持续出现。结论广州地区登革热疫情强度的明显上升、流行趋势的转变以及相同病毒型别的持续,提示广州登革热流行正逐渐呈现由"输入引起的本地传播"向"本地化"进展的趋势。Objective To analyze the epidemic trend of dengue fever in Guangzhou from 2008 to 2017 and provide evidence for the development of prevention and control strategies.Methods Dengue cases information were collected through National Notifiable Infectious Disease Reporting Information System and carried out epidemiological investigation for each dengue outbreak.Descriptive analysis was conducted on the collected epidemic data,and the epidemiological data of 2008-2012 and 2013-2017 were grouped to compare the trend of epidemic situation,duration,coverage,intensity of outbreak and virus type.Results Compared with 2008-2012,the overall scale and annual incidence of dengue fever in Guangzhou increased from 2013 to 2017.The number of imported cases continued to rise.The number of indigenous cases rose rapidly and the duration of the local epidemic was significantly prolonged.The scope of the epidemic expanded from 59 towns in 7 districts during 2008-2012 to cover all 12 districts in Guangzhou and 97.1%（165/170）of towns during 2013-2017.The intensity of the outbreak increased from the limited local outbreak in 2008-2012 to frequent citywide epidemic in 2013-2017.In addition,the number of severe cases and fatal cases increased,and the virus types of the local outbreaks also progressed from sporadic appearance of 4 serotypes to continuously appearance of serotype 1 and 2.Conclusion In recent years,the intensity of dengue fever in Guangzhou has been increased significantly;the change of epidemic trend and the persistence of the same virus type suggested that the epidemic of dengue fever in Guangzhou is gradually progressing from＂imported cases to trigger local transmission＂to local transmission.

关 键 词：登革热 流行病学 

分 类 号：R373.33[医药卫生—病原生物学]