血清白细胞介素21水平与大疱性类天疱疮无相关性  

There is no correlation between the serum level of interleukin-21 and bullous pemphigoid

作　　者：李思哲 闫天萌 李丽 晋红中 左亚刚 Li Sizhe;Yan Tianmeng;Li Li;Jin Hongzhong;Zuo Yagnng(Department of Dermatology,Translational Medicine Center of Peking Union Medical College Hospital,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科协和医学转化中心,北京100730

出　　处：《中华皮肤科杂志》2018年第8期595-596,共2页Chinese Journal of Dermatology

基　　金：国家自然科学基金（81071301）;北京市自然科学基金（7132203）

摘　　要：目的 探讨大疱性类天疱疮（BP）患者血清白细胞介素（IL）21水平与抗BP180抗体、嗜酸性粒细胞（EOS）水平、BP疾病面积指数（BPDAI）的相关性。方法 酶联免疫吸附试验检测31例BP患者和31例健康对照血清IL-21水平，并检测患者血清抗BP180抗体滴度，评估13例患者BPDAI，分析IL-21水平与抗BP180抗体滴度、EOS计数及BPDAI的关系。结果 患者组血清IL-21水平［M（P25 ~ P75）］为255.28（156.19 ~ 361.59） ng/L，健康对照组为150.47（72.4 ~ 268.73） ng/L，两组差异无统计学意义（P = 0.14）。BP患者血清IL-21水平与抗BP180 抗体水平［82.98（26.82 ~ 132.92） U/ml］无统计学相关性（rs＝0.18，P = 0.332）。27例有EOS计数的BP患者中，血清IL-21与全血EOS绝对值无统计学相关性（rs＝0.104，P = 0.606）。13例评估BPDAI的患者中，血清IL-21与BPDAI亦无统计学相关性（rs＝-0.233，P = 0.464）。结论 BP患者IL-21水平与抗BP180抗体、EOS水平、BPDAI均不相关。Objective To investigate the correlations of the serum level of interleukin-21 （IL-21） with anti-BP180 antibodies, peripheral eosinophil level, bullous pemphigoid disease area index （BPDAI）in patients with bullous pemphigoid （BP）. Methods A total of 31 patients with bullous pemphigoid and 31 healthy controls were enrolled into this study. Blood samples were collected from all the subjects, and enzyme-linked immunosorbent assay （ELISA） was performed to detect the serum level of IL-21 and serum titer of anti-BP180 antibodies. BPDAI was assessed among 13 patients, and the correlation of the IL-21 level with anti-BP180 antibody titers, eosinophil count and BPDAI were analyzed. Results No significant difference in the serum level of IL-21 was observed between the patients （M[P25 - P75]： 255.28 [156.19 - 361.59] ng/L） and healthy controls （150.47 [72.4 - 268.73] ng/L, P = 0.14）. There was no correlation between the serum level of IL-21 and serum titer of anti-BP180 antibodies （82.98 [26.82 - 132.92]U/ml, rs = 0.18, P = 0.332）. Among the 27 BP patients who underwent blood cell count, no correlation was found between the serum levels of IL-21 and whole-blood eosinophil counts （rs = 0.104, P = 0.606）. Among the 13 BP patients who underwent assessment of BPDAI, there was no correlation between the serum levels of IL-21 and BPDAI scores （rs = 0.233, P = 0.464）. Conclusion The IL-21 level is uncorrelated with anti-BP180 antibody level, peripheral eosinophil level or BPDAI in patients with BP.

关 键 词：类天疱疮 大疱性 嗜酸细胞 白细胞介素21 抗BP180抗体 

分 类 号：R758.66[医药卫生—皮肤病学与性病学]