内蒙古地区蒙古族、汉族人群瘦素受体基因多态性与原发性高血压的相关性  

Association of single nucleotide polymorphisms of LEPR gene with essential hypertension among ethnic Mongolian and Han Chinese from Inner Mongolia region

作　　者：袁梦露 毕力夫[1] 苏秀兰[1] Yuan Menglu, Bi Lifu, Su Xiulan(Research Center for Clinical Medicine of the Affiliated Hospital, School of Public Health, Inner Mongolia Medical University, Hohhot, Inner Mongolia 010050, Chin)

机构地区：[1]内蒙古医科大学附属医院临床医学研究中心、公共卫生学院,呼和浩特010050

出　　处：《中华医学遗传学杂志》2018年第4期561-566,共6页Chinese Journal of Medical Genetics

基　　金：国家自然科学基金（81260058）

摘　　要：目的探讨瘦素受体（1eptin receptor，LEPR）基因单核苷酸多态性（single nucleotide polymorphism，SNP）与内蒙古地区蒙古族、汉族人群原发性高血压（essential hypertension，EH）及体质指数（bodymassindex，BMI）的关系。方法采用病例一对照研究，用连接酶检测反应（1igase detection reaction，LDR）对内蒙古地区汉族EH患者411例，对照组480名；蒙古族EH患者658例，对照组403名测定LEPR基因各位点基因型，用Logistic回归分析各位点多态性与EH的关系，MDR软件分析位点与环境因素的交互作用模型。结果LEPR基因的rs7555955、rs1137100、rs1137101位点基因型频率在汉族EH和对照组分布差异有统计学意义（P〈0．05）。rs7555955、rsl805094、rsll37100、rsll579567、rsl805134、rs6669354位点基因型频率在蒙古族EH组和对照组分布差异有统计学意义（P（0．05）。Logistic回归分析调整混杂因素后显示，年龄（OR=2．97，95％CI：1．94～3．99）、BMI（OR=3．93，95％CI：2．91～5．96）、rsll37101（AA）（OR=3．96，95％cI：1．32～11．90）是汉族EH独立风险因素。年龄（OR=2．99，95％CI：2．98～4．57）、BMI（OR=3．03，95％CI：1．05～1．27）、rs7555955（AG、GG）（OR=12．12，95％CI：2．80～52．43；OR=6．35，95％CI：1．44～27．94）是蒙古族EH独立的风险因素（P〈0．05）。结论年龄和BMI是汉族、蒙古族EH的独立风险因素，rs1137101位点多态可能与汉族EH有关，rs7555955位点可能与蒙古族EH有关。Objective To assess the association of single nucleotide polymorphisms （SNPs） of leptin receptor （LEPR） gene with essential hypertension （EH） and body mass index （BMI） among ethnic Mongolian and Han Chinese from Inner Mongolia region. Methods In total 411 Han Chinese patients with EH and 480 healthy controls, together with 658 Mongolian patients with EH and 403 healthy controls, were collected. The SNPs of the LEPR gene were determined with ligase detection reaction （LDR）. Logistic regression was used to analyze the association of the polymorphisms of each locus with EH and BMI. MDR software was used to analyze the interaction between above loci and environmental factors. Results Genotypic frequencies of LEPR gene rs7555955, rs1137100 and rs1137101 loci had differed significantly among ethnic Hans with EH and the control group （All P 〈0.05）. While those of rs7555955, rs1805094, rs1137100, rs11579567, rs1805134 and rs6669354 loci had differed significantly among ethnic Mongolians with EH and the control group （All P〈0.05）. After adjustment for confounders, logistic regression analysis indicated that age （OR：2.97, 95%CI：1.94-3.99）, BMI （OR：3.93, 95%CI：2. 91-5. 96）, and rs1137101 （AA） （OR：3. 95, 95%CI： 1.32-11. 90） were independent risk factors for EH among ethnic Hans, while age （OR：2.99, 95%CI..2.98-4.57）, BMI （0R=3.03, 95%CI：1. 05-1. 27）, rs7555955 （AG, AA） （OR： 12.12, 95%CI：2.80- 52.43; OR： 6.35, 95%CI：1. 44-27. 94）, and rs7555955 （GG） were independent risk factors for EH among ethnic Mongolians （P 〈0.05）. Conclusion Age and BMI are independent risk factors for EH in both ethnic Han and Mongolian Chinese. rs1137101 locus is associated with EH among ethnic Hans, while rs7555955 locus is associated with EH among ethnic Mongolians.

关 键 词：瘦素受体基因 单核苷酸多态性 原发性高血压 

分 类 号：R440[医药卫生—诊断学] R544.11[医药卫生—临床医学]