类泛素化修饰(SUMOylation)与基因组稳定性  

Ubiquitin-like modification(SUMOylation) and genomic stability

作　　者：程金科[1] CHENG Jin-ke(Department of Biochemistry and Molecular Cell Biology,Shanghai Jiao Tong University College of Basic Medical Sciences,Shanghai Key Laboratory for Tumor Microenvironment and Inflammation,Shanghai 200025,Chin)

机构地区：[1]上海交通大学基础医学院生物化学与分子细胞生物学系、上海市肿瘤微环境与炎症重点实验室,上海200025

出　　处：《上海交通大学学报（医学版）》2018年第7期719-721,共3页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家自然科学基金(81430069,81721004) 研究得到国家自然科学基金的资助.

摘　　要：蛋白质翻译后修饰在细胞有丝分裂和基因组稳定性中的作用机制一直是生物学研究的热点。该文主要介绍蛋白去SUMO化修饰酶SENP3在细胞有丝分裂期姐妹染色体分离中的作用,以及蛋白SUMO化修饰和磷酸化修饰的相互调控作用在维持细胞基因组稳定性中新的分子机制。The mechanism of protein post-translational modifications in regulation of cell mitosis and genomic stability is always a hot issue in biological researches.The present review introduced the functional activity of de-SUMOylase SENP3 in sister chromatin dissociation at mitosis,and demonstrated a new molecular mechanism of cross-talk regulation between protein SUMOylation and phosphorylation in maintaining genomic stability.

关 键 词：SUMO化 磷酸化 SENP3 

分 类 号：Q75[生物学—分子生物学]