银杏内酯注射液治疗出血性脑梗死的临床安全性有效性分析  

Safety and efficacy of Ginkgolide Injection in treating hemorrhagic cerebral infarction

作　　者：冯 毕思伟 李莉[1] 王雅君[1] 唐磊 王娇 FENG Yan;BI Siwei;LI Li;WANG Yajun;TANG Lei;WANG Jiao(Department of Neurology,Shenyang First People＇s Hospital,Shenyang 110041,China)

机构地区：[1]沈阳市第一人民医院神经内科,辽宁沈阳110041

出　　处：《药物评价研究》2018年第7期1179-1184,共6页Drug Evaluation Research

摘　　要：目的研究银杏内酯注射液治疗出血性脑梗死的安全性和有效性。方法选取沈阳市第一人民医院2016年1月—2017年12月收治的出血性脑梗死患者81例,随机分为2组,对照组予以常规药物治疗,治疗组在其基础上加用银杏内酯注射液10 m L/次,生理盐水250 m L稀释,静脉滴注,每天1次,连续使用14 d。观察治疗后的不良反应、出血转化情况,比较治疗7、14、90 d后患者的美国国立卫生研究院卒中量表(NIHSS)、m RS和ADL评分。结果对照和治疗组未出现药物过敏及肝、肾功能恶化等不良反应,影像学观察未见出血扩大,脑水肿明显减轻。治疗组和对照组在用药7 d后各项评分指标未见明显统计学差异;而在治疗14、90 d后,治疗组的NIHSS评分、m RS评分较对照组显著降低,ADL评分显著提高,两组差异具有统计学意义(P<0.05)。结论银杏内酯注射液不会增加出血性脑梗死患者的出血扩大,且能减轻脑水肿,改善患者神经功能缺损,治疗出血性脑梗死安全有效。Objective To investigate the safety and efficacy of Ginkgolide Injection in treating hemorrhagic cerebral infarction. Methods Totally 81 patients with hemorrhagic cerebral infarction admitted to the first people＇s hospital of shenyang in January 2016 to December 2017 were randomly divided into two groups. The control group were treated with routine drugs, and the treatment group were treated with Ginkgolide Injection on the basis of routine drugs with 10 mL＋0.9% NS, once daily for 14 d. The observation of the transformations of the hemorrhage and adverse reaction after treatment was carried out, and the comparation of the NIHSS, mRS and ADL scores of patients with treatment for 7, 14 and 90 d was done. Results No adverse reactions of drug allergy and deterioration of liver and kidney function were observed in the two groups. The imaging observation of treatment group showed no increase in hemorrhage, and the cerebral edema was significantly reduced. There was no statistically significant difference in the score indicators between treatment group and control group after 7 d of medication, The NIHSS scores and mRS scores of treatment group were significantly lower than those of control group, and the ADL scores were significantly improved, and the difference between the two groups was statistically significant（P〈0.05）. Conclusion Ginkgolide Injection do not increase hemorrhage in patients with hemorrhagic cerebral infarction, and which can reduce cerebral edema, improve the neurological deficit of patients. Ginkgolide Injection is safe and effective in treating hemorrhagic cerebral infarction.

关 键 词：银杏内酯注射液 出血性脑梗死 脑水肿 安全性 有效性 

分 类 号：R962.2[医药卫生—药理学]