桂枝茯苓丸联合炔雌醇环丙孕酮片和枸橼酸氯米芬胶囊对多囊卵巢综合征后妊娠和心理状态的影响  

Influence of Taie-35 and Clomifen combined with Laurel cocos poria pill on the pregnancy and psychological state of polycystic ovary syndrome patients

作　　者：罗健[1] 聂润球[1] 林丽仪[1] LUO Jian;NIE Runqiu;LIN Liyi(Gynecology Department,Foshan Hospital of TCM,Foshan 528000,Chin)

机构地区：[1]佛山市中医院妇科,广东佛山528000

出　　处：《药物评价研究》2018年第7期1300-1303,共4页Drug Evaluation Research

摘　　要：目的探讨桂枝茯苓丸联合炔雌醇环丙孕酮片和枸橼酸氯米芬胶囊对多囊卵巢综合征后妊娠和心理状态的影响。方法以2012年2月—2016年2月佛山市中医院收治的96例多囊卵巢综合征患者为研究对象。按就诊时间先后顺序分为对照组和观察组各48例。对照组给予炔雌醇环丙孕酮片和枸橼酸氯米芬胶囊治疗,观察组在对照组治疗基础上加服桂枝茯苓丸。两组均为21 d为1周期,6个周期为1疗程。比较两组治疗前后的血清性激素、心理状态和治疗后1年内的妊娠情况。结果治疗前,两组的血清性激素水平差异无统计学意义;两组治疗后的血清性激素水平均低于治疗前,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,观察组的黄体生成素(LH)和睾酮(T)水平低于对照组,差异有统计学意义(P<0.05)。治疗前,两组的SAS和SDS评分均无统计学差异;两组治疗后的SAS和SDS评分均低于治疗前,同组治疗前后比较差异有统计学意义(P<0.05);治疗后,观察组的SAS和SDS评分均低于对照组,差异有统计学意义(P<0.05)。观察组的妊娠率和足月分娩率高于对照组,差异有统计学意义(P<0.05);两组的流产率和早产率差异无统计学意义。结论桂枝茯苓丸联合炔雌醇环丙孕酮片和枸橼酸氯米芬胶囊治疗多囊卵巢综合征,有利于调节血清性激素水平,提高妊娠率和足月分娩率,并可改善患者不良心理,值得临床推广。objective To discuss the influence of Taie-35 and Clomifen combined with Laurel cocos poria pill on the pregnancy and psychological state of polycystic ovary syndrome patients. Methods A total of 96 polycystic ovary syndrome patients patientstreated in Foshan Hospital of TCM from February 2012 to February 2016 were studied and were divided into control group（48 cases） and observation group（48 cases） according to the time of admission. Control group received Taie-35 and Clomifen treatment. And observation group was treated with Laurel cocos poria pill on the base of control group. Serum sex hormone levels, psychological state and pregnancy of two groups were compared. Results Before treatment, the difference in serum sex hormone levels between two groups was not statistically significant. Serum sex hormone levels of two groups after treatment were lower than those before treatment（P〈0.05）. After treatment, luteinizing hormone（LH） and testosterone（T） of observation group were lower than those of control group（P〈0.05）. Before treatment, the differences in SAS and SDS scores between two groups were not statistically significant. SAS and SDS scores of two groups after treatment were lower than those before treatment（P〈0.05）. After treatment, SAS and SDS scores of observation group were lower than those of control group（P〈0.05）. After treatment, pregnancy rate and term delivery rate of observation group were higher than those of control group（P〈0.05）. The differences in miscarriage rate and preterm birth rate between two groups were not statistically significant. Conclusion Taie-35 and Clomifen combined with Laurel cocos poria pill in treatment with polycystic ovary syndrome is helpful to adjust serum sex hormone level, increase pregnancy rate and term delivery rate, improve the patients＇ bad psychology and deserve clinical promotion.

关 键 词：多囊卵巢综合征 心理状态 炔雌醇环丙孕酮片 枸橼酸氯米芬胶囊 桂枝茯苓丸 

分 类 号：R917[医药卫生—药物分析学]