放射性同位素示踪技术在药物研发过程中的应用  

Application of radiolabeled isotope tracing technology in drug development

作　　者：李亚卓[1,2] 慈小燕[1,2] 伊秀林[1,2] 曾勇[1,2] 刘昌孝[1,2] LI Yazhuo;CI Xiaoyan;YI Xiulin;ZENG Yong;LIU Changxiao(Tianjin Institute of Pharmaceutical Research,State Key Laboratory of Drug Technologies and Pharmacokinetics,Tianjin 300193,China;Tianjin Institute of Pharmaceutical Research New Drug Assessment Co.Ltd.,Tianjin 300301,China)

机构地区：[1]天津药物研究院释药技术与药代动力学国家重点实验室,天津300193 [2]天津药物研究院新药评价有限公司,天津300301

出　　处：《药物评价研究》2018年第7期1348-1356,共9页Drug Evaluation Research

摘　　要：药物的吸收、分布、代谢和排泄过程决定了药物分子在体内的过程和命运。作为常规生物样本检测技术的有效补充,放射性同位素标记示踪技术如今也被广泛应用于药物发现和开发过程中的各个阶段。特别是其高灵敏性、适用范围广的特点使其具有不可比拟的优势。通过对近年来放射性标记技术在药物评价领域中的应用进行了归纳和梳理,为药物研发相关领域研究人员提供可借鉴的参考。The in vivo process and fate of drug molecules are determined by its absorption, tissue distribution, metabolism and excretion. As an effective complementary to conventional biological sample measurements. Radiolabeled isotope tracing technology has been widespread applied in all stages of drug discovery and development. Due to its high sensitivity and applicability, the radiolabeled approach exhibits advantages. In the review, the application of radiolabeled tracing technology has been reviewed and summarized, which may provide valuable information for scientists in this field.

关 键 词：放射性同位素示踪 跨膜转运 药物转运蛋白 药物代谢 药物安全性 

分 类 号：R282.71[医药卫生—中药学]