G蛋白耦联雌激素受体介导雌激素治疗机制研究进展  

Advances in the mechanism of G protein coupled estrogen receptor mediated estrogen therapy

作　　者：胡江珊[1] 陶敏芳[1] Hu Jiangshan;Tao Minfang(Department of Gynecology and Obstetrics,Shanghai Jiao Tong University Affiliated Sixth People＇s Hospital,Shanghai 200233,Chin)

机构地区：[1]上海交通大学附属第六人民医院妇产科,200233

出　　处：《中华生殖与避孕杂志》2018年第6期472-476,共5页Chinese Journal of Reproduction and Contraception

摘　　要：女性绝经后会出现一系列与雌激素缺乏有关的症状和疾病,补充雌激素是目前主要的治疗方法。雌激素除了通过与传统的核受体ERα、β结合产生基因组效应外,雌激素膜受体-G蛋白耦联雌激素受体(G protein-coupled estrogen receptor,GPER)介导的雌激素对靶器官的快速效应也得到了证实。近些年,关于GPER介导雌激素在不同靶细胞的特异生理功能及其作用机制的研究层出不穷,本文从生殖系统、神经系统、心血管系统、内分泌代谢及骨代谢方面,综述这些年来研究发现的GPER介导的雌激素作用的相关机制。There will be a series of symptoms and diseases associated with estrogen deficiency after menopause, and the main treatment is menopause hormone therapy. In addition to the genomic effects of estrogen binding to the traditional nuclear receptors ERα and β, a recently discovered G protein-coupled estrogen receptor（GPER） has also confirmed the rapid effects of estrogen on target organs. In recent years, studies on GPERmediated estrogen specific physiological functions in different target cells and its mechanism of action are emerging. This review summarizes the possible mechanisms of GPER mediated estrogen therapy in the treatment of menopausal symptoms and diseases from the aspects of reproductive system, nervous system, cardiovascular system, endocrine metabolism and bone metabolism.

关 键 词：绝经 雌激素 G蛋白耦联雌激素受体(GPER) G蛋白耦联受体30(GPR30) 激素补充治疗 

分 类 号：R711.75[医药卫生—妇产科学]